Trial reportAntimicrobial agents and chemotherapy1993
Liposome-encapsulated gentamicin treatment of Mycobacterium avium-Mycobacterium intracellulare complex bacteremia in AIDS patients.
Trial report in Antimicrobial agents and chemotherapy, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 55 citations in OpenAlex.
- Liposome-Encapsulated Antibiotics for the Therapy of Mycobacterial Infections.Antibiotics (Basel, Switzerland) · 2025Review
- The Case against Antibiotics and for Anti-Virulence Therapeutics.Microorganisms · 2021Review
- Clinical Translation of Nanomedicine.Chemical reviews · 2015Review
- Efficacy of liposome-encapsulated ciprofloxacin in a murine model of Q fever.Antimicrobial agents and chemotherapy · 2014Article
- Prevention and treatment of biofilms by hybrid- and nanotechnologies.International journal of nanomedicine · 2013Review
- Efficacy of microencapsulated rifampin in Mycobacterium tuberculosis-infected mice.Antimicrobial agents and chemotherapy · 1999Article
- Pharmacokinetics and urinary excretion of amikacin in low-clearance unilamellar liposomes after a single or repeated intravenous administration in the rhesus monkey.Antimicrobial agents and chemotherapy · 1999Article
- Altered tissue distribution and elimination of amikacin encapsulated in unilamellar, low-clearance liposomes (MiKasome).Pharmaceutical research · 1998Article
- Use of microsphere technology for targeted delivery of rifampin to Mycobacterium tuberculosis-infected macrophages.Antimicrobial agents and chemotherapy · 1998Article
- Intracellular delivery and antibacterial activity of gentamicin encapsulated in pH-sensitive liposomes.Antimicrobial agents and chemotherapy · 1998Article
- Antibacterial efficacy against an in vivo Salmonella typhimurium infection model and pharmacokinetics of a liposomal ciprofloxacin formulation.Antimicrobial agents and chemotherapy · 1998Article
- Therapeutic efficacies of isoniazid and rifampin encapsulated in lung-specific stealth liposomes against Mycobacterium tuberculosis infection induced in mice.Antimicrobial agents and chemotherapy · 1997Article
- Mycobacterium avium complex infection. Pharmacokinetic and pharmacodynamic considerations that may improve clinical outcomes.Clinical pharmacokinetics · 1997Review
- Liposomes as delivery systems in the prevention and treatment of infectious diseases.Pharmacy world & science : PWS · 1995Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TLC G-65, a liposome-encapsulated gentamicin, was given intravenously twice weekly for 4 weeks to AIDS patients with Mycobacterium avium-M. intracellulare complex (MAC) bacteremia at 1.7 mg of gentamicin per kg of body weight per infusion (4 patients), 3.4 mg/kg (10 patients), and 5.1 mg/kg (7 patients). MAC colony counts in blood fell by 75% or more in all three groups (P < 0.005). Drug resistance did not emerge during the study period. Transient renal insufficiency developed in one patient; no other adverse effects were detected. Liposome-encapsulated gentamicin is a potential therapy for MAC infections in AIDS patients.
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