ArticleVeterinary immunology and immunopathology1993
Age-related increase of porcine natural interferon alpha producing cell frequency and of interferon yield per cell.
Article in Veterinary immunology and immunopathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Cytokines and synthetic double-stranded RNA augment the T helper 1 immune response of swine to porcine reproductive and respiratory syndrome virus.Veterinary immunology and immunopathology · 2004Trial
- Oral treatment of transmissible gastroenteritis with natural human interferon alpha: a field study.Veterinary immunology and immunopathology · 1995Trial
- Therapeutic and Prophylactic Use of Oral, Low-Dose IFNs in Species of Veterinary Interest: Back to the Future.Veterinary sciences · 2021Review
- Effect of Porcine Epidemic Diarrhea Virus Infectious Doses on Infection Outcomes in Naïve Conventional Neonatal and Weaned Pigs.PloS one · 2015Article
- Characterization of the cytokine and maturation responses of pure populations of porcine plasmacytoid dendritic cells to porcine viruses and toll-like receptor agonists.Veterinary immunology and immunopathology · 2010Article
- Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function.Nature reviews. Immunology · 2010Review
- Structure-dependent modulation of alpha interferon production by porcine circovirus 2 oligodeoxyribonucleotide and CpG DNAs in porcine peripheral blood mononuclear cells.Journal of virology · 2007Article
- Article
- Interferon-alpha production and tissue localization of interferon-alpha/beta producing cells after intradermal administration of Aujeszky's disease virus-infected cells in pigs.Scandinavian journal of immunology · 1995Article
- Ontogeny of interferon alpha secreting cells in the porcine fetal hematopoietic organs.Immunology letters · 1994Article
- Influence of experimentally induced endogenous production of cortisol on the immune capacity in swine.Veterinary immunology and immunopathology · 1994Article
- Genetic variation in parameters reflecting immune competence of swine.Veterinary immunology and immunopathology · 1994Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porcine blood mononuclear cells (PBMC) were shown to secrete interferon alpha (IFN-alpha) after induction by a coronavirus, the transmissible gastroenteritis virus (TGEV). IFN-alpha producing cells, referred to as natural interferon alpha producing (NIP) cells, were detected by an ELISPOT assay using anti-porcine IFN-alpha monoclonal antibodies. The frequency of NIP cells among blood cells is low, at most 40-110 per 10(5) PBMC and each NIP cell was found to produce several units of IFN. We have shown that NIP cell frequency and IFN yield per cell gradually increased with the age of the donor animals, from the neonatal period to the adult age, with a significant increase around puberty. Our present results also indicate that NIP cells may be influenced by physiological and genetic factors; thus (1) NIP cell frequency and IFN yield per cell were decreased during lactation; (2) Chinese (Meishan) pigs were found to have higher NIP cell frequency and IFN yield per cell than European (Large White) animals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.