Evidence map›Paper›PMID 8234252›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1993

Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base.

S Tugendreich, M S Boguski, M S Seldin, P Hieter

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 55 citations in OpenAlex.

  1. POLD3 as Controller of Replicative DNA Repair.International journal of molecular sciences · 2024
    Review
  2. Article
  3. Article
  4. Profile of Philip Hieter.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  5. Article
  6. Medicago truncatula EST-SSRs reveal cross-species genetic markers for Medicago spp.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2004
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Efficient manipulation of the human adenovirus genome as an infectious yeast artificial chromosome clone.Proceedings of the National Academy of Sciences of the United States of America · 1994
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

S TugendreichDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
M S Boguski
M S Seldin
P Hieter
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

TRANSPOSITION OF TN7P01CA016519 · NCI · JOHNS HOPKINS UNIVERSITY · PI BOEKE, JEF D · 1985 to 2010
$21.4M
MOLECULAR GENETICS OF TUMOR VIRUSES AND CELLST32CA009139 · NCI · JOHNS HOPKINS UNIVERSITY · PI GREIDER, CAROL W · 1985 to 2005
$2.6M
NCI NIH HHS 5T32CA09139NCI NIH HHS CA16519NHGRI NIH HHS HG-00101
6 · The paper itself

Abstract

We describe a strategy for quickly identifying and positionally mapping human homologs of yeast genes to cross-reference the biological and genetic information known about yeast genes to mammalian chromosomal maps. Optimized computer search methods have been developed to scan the rapidly expanding expressed sequence tag (EST) data base to find human open reading frames related to yeast protein sequence queries. These methods take advantage of the newly developed BLOSUM scoring matrices and the query masking function SEG. The corresponding human cDNA is then used to obtain a high-resolution map position on human and mouse chromosomes, providing the links between yeast genetic analysis and mapped mammalian loci. By using these methods, a human homolog of Saccharomyces cerevisiae CDC27 has been identified and mapped to human chromosome 17 and mouse chromosome 11 between the Pkca and Erbb-2 genes. Human CDC27 encodes an 823-aa protein with global similarity to its fungal homologs CDC27, nuc2+, and BimA. Comprehensive cross-referencing of genes and mutant phenotypes described in humans, mice, and yeast should accelerate the study of normal eukaryotic biology and human disease states.

Indexed as

Cell Cycle ProteinsDatabases, FactualAmino Acid SequenceAnimalsApc3 Subunit, Anaphase-Promoting Complex-CyclosomeChromosome MappingChromosomes, Human, Pair 17Conserved SequenceCrosses, GeneticDNA, ComplementaryFungal ProteinsGenomeHominidaeHumansMiceMice, Inbred C3HApc3 Subunit, Anaphase-Promoting Complex-CyclosomeCDC27 protein, humanCDC27 protein, S cerevisiaeCell Cycle ProteinsDNA, ComplementaryFungal ProteinsSaccharomyces cerevisiae ProteinsUbiquitin-Protein Ligases

Identifiers

PMID8234252
PMCPMC47707
OpenAlexW2076447167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.