ArticleNucleic acids research1993
SnoI, a novel alternatively spliced isoform of the ski protooncogene homolog, sno.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- SnoN Antagonizes the Hippo Kinase Complex to Promote TAZ Signaling during Breast Carcinogenesis.Developmental cell · 2016Article
- Invited review: mesenchymal progenitor cells in intramuscular connective tissue development.Animal : an international journal of animal bioscience · 2016Review
- The influence of SnoN gene silencing by siRNA on the cell proliferation and apoptosis of human pancreatic cancer cells.Diagnostic pathology · 2015Article
- Article
- Cooperative involvement of NFAT and SnoN mediates transforming growth factor-β (TGF-β) induced EMT in metastatic breast cancer (MDA-MB 231) cells.Clinical & experimental metastasis · 2013Article
- Expression profiles of SnoN in normal and cancerous human tissues support its tumor suppressor role in human cancer.PloS one · 2013Article
- SnoN in regulation of embryonic development and tissue morphogenesis.FEBS letters · 2012Review
- Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-beta gene is mediated by differential expression of positive regulatory activator protein 1 factors and corepressors SKIL and TGIF1.Molecular endocrinology (Baltimore, Md.) · 2011Article
- ZAS3 accentuates transforming growth factor β signaling in epithelial cells.Cellular signalling · 2011Article
- SnoN in mammalian development, function and diseases.Current opinion in pharmacology · 2010Review
- The crystal structure of the Dachshund domain of human SnoN reveals flexibility in the putative protein interaction surface.PloS one · 2010Article
- Transforming growth factor-beta regulator SnoN modulates mammary gland branching morphogenesis, postlactational involution, and mammary tumorigenesis.Cancer research · 2010Article
- SnoN functions as a tumour suppressor by inducing premature senescence.The EMBO journal · 2009Article
- Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3.The Journal of biological chemistry · 2009Article
- Ski and SnoN, potent negative regulators of TGF-beta signaling.Cell research · 2009Review
- Dual role of SnoN in mammalian tumorigenesis.Molecular and cellular biology · 2007Article
- Requirement for the SnoN oncoprotein in transforming growth factor beta-induced oncogenic transformation of fibroblast cells.Molecular and cellular biology · 2005Article
- Article
- Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN.Genes & development · 2001Article
- The Max network gone mad.Molecular and cellular biology · 2001Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
We have cloned and sequenced a novel human isoform of sno, snoI for insertion. SnoI contains 1330 nucleotides inserted in place of 7 nucleotides of the snoN mRNA. Sno is a member of the ski protooncogene family, which has been implicated in muscle development. The two previously known sno alternatively spliced isoforms are snoN (684 amino acids), and snoA (415 amino acids); snoI encodes a truncated isoform of 399 amino acids (44,298 MW). Southern blot experiments show that snoI contains a third alternative exon from the sno gene; a single sno gene can express all three isoforms of sno by alternative splicing. All three isoforms contain the region that is most similar to the ski proto-oncogene. The relationship between snoI and snoN is analogous to that between delta fosB and fosB, where a truncated form of the fosB transcription factor is produced by alternative splicing. We find conservation of human snoI-specific sequences in several mammalian species, in monkey, dog, cow, rabbit and pig, but not in rodents, whereas the common portion of the sno gene is conserved in all vertebrate species tested. SnoN, snoA, and ski mRNAs accumulate in many human tissues including skeletal muscle; the snoI alternative mRNA accumulates more specifically in skeletal muscle. SnoI is also expressed in rhabdomyosarcoma tumor, a tumor that contains differentiated skeletal muscle. The tissue-specific alternative splicing of human snoI, an mRNA in the ski/sno gene family, and the presence of sno mRNAs in muscle are consistent with a proposed role for the sno oncogene in muscle gene regulation.
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Registered trials
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