ArticleNucleic acids research1993
HAPPY mapping of a YAC reveals alternative haplotypes in the human immunoglobulin VH locus.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses.Frontiers in virology (Lausanne, Switzerland) · 2023Article
- Estimating Copy Number and Allelic Variation at the Immunoglobulin Heavy Chain Locus Using Short Reads.PLoS computational biology · 2016Article
- Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation.American journal of human genetics · 2013Article
- The immunoglobulin heavy chain locus: genetic variation, missing data, and implications for human disease.Genes and immunity · 2012Review
- The inference of phased haplotypes for the immunoglobulin H chain V region gene loci by analysis of VDJ gene rearrangements.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Segmental duplication as one of the driving forces underlying the diversity of the human immunoglobulin heavy chain variable gene region.BMC genomics · 2011Article
- Development and initial characterization of a HAPPY panel for mapping the X. tropicalis genome.International journal of biological sciences · 2011Article
- Article
- Determination of gene organization in the human IGHV region on single chromosomes.Genes and immunity · 2005Article
- Direct detection of insertion/deletion polymorphisms in an autosomal region by analyzing high-density markers in individual spermatozoa.American journal of human genetics · 2002Article
- A high-resolution HAPPY map of Dictyostelium discoideum chromosome 6.Genome research · 2000Article
- The super-information age of immunoglobulin genetics.The Journal of experimental medicine · 1998Article
- Determination of gene organization in individual haplotypes by analyzing single DNA fragments from single spermatozoa.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- The human immunoglobulin V(H) gene repertoire is genetically controlled and unaltered by chronic autoimmune stimulation.The Journal of clinical investigation · 1996Article
- Expression of the immunoglobulin VH gene 51p1 is proportional to its germline gene copy number.The Journal of clinical investigation · 1996Article
- Ethnic differences of polymorphism of an immunoglobulin VH3 gene.The Journal of clinical investigation · 1995Article
- Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus.The Journal of clinical investigation · 1995Article
- Analysis of human VH gene repertoire expression in peripheral CD19+ B cells.Immunogenetics · 1995Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified and sequenced 14 human immunoglobulin VH segments cloned in a yeast artificial chromosome, and have used a rapid PCR-based technique (HAPPY mapping, 12) to derive the order and approximate distances between them. The sequences mapped comprise thirteen germline VH segments and one rearranged VH3 gene. Comparison of our map with other data suggests the existence of at least two distinct haplotypes, differing in the presence or absence of the consecutive genes DP-78, DP-46 and DP-64, and in the duplication of segments DP-49 and DP-65. Screening of ten individuals confirms the existence of both haplotypes, and indicates that both are common amongst the population.
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