ArticleJournal of virology1993
Molecular mimicry between the human immunodeficiency virus type 1 gp120 V3 loop and human brain proteins.
Article in Journal of virology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Human Immunodeficiency Virus Proteins Mimic Human T Cell Receptors Inducing Cross-Reactive Antibodies.International journal of molecular sciences · 2017Article
- CNS demyelinating disorder with mixed features of neuromyelitis optica and multiple sclerosis in HIV-1 infection. Case report and literature review.Journal of neurovirology · 2014Review
- Immune activation, viral gene product expression and neurotoxicity in the HIV-1 transgenic rat.Journal of neuroimmunology · 2012Article
- Inflammatory papillomatous hyperplasia and epidermal necrosis in a transgenic rat for HIV-1.Journal of dermatological science · 2009Article
- Noninfectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Artificial mosaic protein containing antigenic epitopes of hepatitis E virus.Journal of virology · 1994Article
- Cross-reactivity of anti-human immunodeficiency virus type 1 gp41 antibodies with human astrocytes and astrocytoma cell lines.Journal of virology · 1994Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Immunologically cross-reactive proteins in the human brain that resemble the V3 loop of human immunodeficiency virus type 1 (HIV-1) gp120 have been identified. When several homogenized tissues from normal brains were used, a monoclonal antibody raised against amino acids 308 to 320 of the V3 loop reacted with three prominent human brain proteins (HBP) of 35, 55, and 110 kDa. Among the three, the 55-kDa HBP appears to be specific to the central nervous system. These results indicate that the V3 loop of HIV-1 gp120 shares an epitope with HBP. An immune response to the V3 loop that generates cross-reactive antibodies to cellular proteins may be an autoimmune mechanism by which HIV-1 can damage the central nervous system.
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Registered trials
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