ArticleJournal of virology1993
Characterization of mouse hepatitis virus-specific cytotoxic T cells derived from the central nervous system of mice infected with the JHM strain.
Article in Journal of virology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Vaccination strategies to combat novel corona virus SARS-CoV-2.Life sciences · 2020Review
- SARS vaccines: where are we?Expert review of vaccines · 2009Review
- Genomic RNA sequence of feline coronavirus strain FCoV C1Je.Journal of feline medicine and surgery · 2007Article
- Anatomical and cellular requirements for the activation and migration of virus-specific CD8+ T cells to the brain during Theiler's virus infection.Journal of virology · 2005Article
- Generation and characterization of DNA vaccines targeting the nucleocapsid protein of severe acute respiratory syndrome coronavirus.Journal of virology · 2004Article
- Kinetics of virus-specific CD8+ -T-cell expansion and trafficking following central nervous system infection.Journal of virology · 2003Article
- Functional expression of chemokine receptor CCR5 on CD4(+) T cells during virus-induced central nervous system disease.Journal of virology · 2003Article
- B-cell-mediated lysis of cells infected with the neurotropic JHM strain of mouse hepatitis virus.Virology · 2001Article
- Viral induced demyelination.Brain pathology (Zurich, Switzerland) · 2001Review
- Regulation of T cell responses during central nervous system viral infection.Advances in virus research · 2001Review
- Induction of apoptosis in murine coronavirus-infected cultured cells and demonstration of E protein as an apoptosis inducer.Journal of virology · 1999Article
- Prevalent class I-restricted T-cell response to the Theiler's virus epitope Db:VP2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28.Journal of virology · 1999Article
- Pseudorabies virus-induced leukocyte trafficking into the rat central nervous system.Journal of virology · 1998Article
- Cytotoxic T-cell-resistant variants arise at early times after infection in C57BL/6 but not in SCID mice infected with a neurotropic coronavirus.Journal of virology · 1997Article
- Specificity of the H-2 L(d)-restricted cytotoxic T-lymphocyte response to the mouse hepatitis virus nucleocapsid protein.Journal of virology · 1996Article
- CD8+ T-cell epitopes within the surface glycoprotein of a neurotropic coronavirus and correlation with pathogenicity.Journal of virology · 1995Article
- Mouse hepatitis virus A59-induced demyelination can occur in the absence of CD8+ T cells.Microbial pathogenesis · 1995Article
- Mouse hepatitis virus-specific cytotoxic T lymphocytes protect from lethal infection without eliminating virus from the central nervous system.Journal of virology · 1995Article
- Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis.Journal of virology · 1994Article
- Characterization of the Ld-restricted cytotoxic T-lymphocyte epitope in the mouse hepatitis virus nucleocapsid protein.Journal of virology · 1993Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The cytotoxic T lymphocyte (CTL) activity of spleen cells from BALB/c (H-2d) mice immunized with the neurotropic JHM strain of mouse hepatitis virus (JHMV) was stimulated in vitro for 7 days. CTL were tested for recognition of target cells infected with either JHMV or vaccinia virus recombinants expressing the four virus structural proteins. Only target cells infected with either JHMV or the vaccinia virus recombinant expressing the JHMV nucleocapsid protein were recognized. Cytotoxic T cell lines were established by limiting dilution from the brains of mice undergoing acute demyelinating encephalomyelitis after infection with JHMV. Twenty of the 22 lines recognized JHMV-infected but not uninfected syngeneic target cells, indicating that they are specific for JHMV. All T-cell lines except one were CD8+. The specificity of the CTL lines was examined by using target cells infected with vaccinia virus recombinants expressing the JHMV nucleocapsid, spike, membrane, and hemagglutinin-esterase structural proteins. Seventeen lines recognized target cells expressing the nucleocapsid protein. Three of the JHMV-specific T-cell lines were unable to recognize target cells expressing any of the JHMV structural proteins, indicating that they are specific for an epitope of a nonstructural protein(s) of JHMV. These data indicate that the nucleocapsid protein induces an immunodominant CTL response. However, no CTL activity specific for the nucleocapsid protein could be detected in either the spleens or cervical lymph nodes of mice 4, 5, 6, or 7 days after intracranial infection, suggesting that the CTL response to JHMV infection within the central nervous system may be induced or expanded locally.
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