ArticleThe Journal of experimental medicine1993
Distribution and kinetics of superantigen-induced cytokine gene expression in mouse spleen.
Article in The Journal of experimental medicine, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 114 citations in OpenAlex.
- Hs-CRP and TNF-α Effects on Postnatal Umbilical Coiling: Impact Assessment of the Gestational Diabetes Mellitus.Medical journal of the Islamic Republic of Iran · 2023Article
- Are superantigens the cause of cytokine storm and viral sepsis in severe COVID-19? Observations and hypothesis.Scandinavian journal of immunology · 2020Article
- SpeS: A Novel Superantigen and Its Potential as a Vaccine Adjuvant against Strangles.International journal of molecular sciences · 2020Article
- MiR-222 inhibition alleviates Staphylococcal Enterotoxin B-induced inflammatory acute lung injury by targeting Foxo3.Journal of biosciences · 2020Article
- Superantigen influence in conjunction with cytokine polymorphism potentiates autoimmunity in systemic lupus erythematosus patients.Immunologic research · 2016Article
- Reverse genetics of rabies virus: new strategies to attenuate virus virulence for vaccine development.Journal of neurovirology · 2015Article
- Staphylococcal enterotoxin B-induced microRNA-155 targets SOCS1 to promote acute inflammatory lung injury.Infection and immunity · 2014Article
- Glucose, insulin, and oxygen interplay in placental hypervascularisation in diabetes mellitus.BioMed research international · 2014Review
- Staphylococcal entertotoxins of the enterotoxin gene cluster (egcSEs) induce nitrous oxide- and cytokine dependent tumor cell apoptosis in a broad panel of human tumor cells.Frontiers in cellular and infection microbiology · 2013Article
- Brain-immune interactions and the neural basis of disease-avoidant ingestive behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Clarifying the mechanism of superantigen toxicity.PLoS biology · 2011Article
- Kinetics of proinflammatory cytokines after intraperitoneal injection of tribromoethanol and a tribromoethanol/xylazine combination in ICR mice.Laboratory animal research · 2011Article
- The role of atorvastatin in regulating the immune response leading to vascular damage in a model of Kawasaki disease.Clinical and experimental immunology · 2011Article
- Influence of age on behavioral, immune and endocrine responses to the T-cell superantigen staphylococcal enterotoxin A.The European journal of neuroscience · 2009Article
- How T-cell-dependent and -independent challenges access the brain: vascular and neural responses to bacterial lipopolysaccharide and staphylococcal enterotoxin B.Brain, behavior, and immunity · 2009Article
- Relationship of varying patterns of cytokine production to the anorexic and neuroendocrine effects of repeated Staphylococcal enterotoxin A exposure.Journal of neuroimmunology · 2008Article
- The strange case of TGN1412.Cancer immunology, immunotherapy : CII · 2007Review
- Lipopolysaccharide-induced upregulation of tumor necrosis factor-alpha (TNF-alpha) and TNF receptors in rat sciatic nerve.Journal of molecular neuroscience : MN · 2007Article
- Hypothalamic integration of immune function and metabolism.Progress in brain research · 2006Review
- Overexpression of tumor necrosis factor alpha by a recombinant rabies virus attenuates replication in neurons and prevents lethal infection in mice.Journal of virology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The polyclonal stimulation of T cells by bacterial superantigens is involved in the pathogenesis of the toxic shock syndrome in certain staphylococcal and streptococcal infections. Here we describe the onset and kinetics of superantigen-induced cytokine production in situ in spleens of normal BALB/c mice monitored at the level of cytokine mRNA expression by in situ hybridization. Messenger RNAs for interleukin 2 (IL-2), interferon gamma, and tumor necrosis factors (TNF) alpha and beta were not expressed at detectable levels in spleens of unstimulated animals but became visible already 30 min after intraperitoneal application of 50 micrograms staphylococcal enterotoxin B. All mRNA levels showed peak expression approximately 3 h after injection and a slow decrease up to 24 h after injection. Expression of the mRNAs was restricted to the T cell-dependent area of the periarteriolar lymphatic sheets of the spleen. Interestingly, TNF-alpha mRNA showed a biphasic response, the early appearing mRNA had the same localization as the other mRNAs, whereas after 3 h TNF-alpha mRNA showed a broader distribution indicating a second cell population producing TNF-alpha. The expression of IL-2 and TNF proteins in the serum increased in parallel to the observed mRNA changes with a slight delay. The presence of macrophages was not required for the expression of the cytokine mRNAs in the spleen as the expression was unchanged in macrophage-depleted mice. Only the second phase of TNF-alpha mRNA expression was abrogated in such animals. The expression of all mRNAs was completely suppressed by prior administration of cyclosporin A. These data show that nonphagocytic cells are the essential superantigen-presenting cells in vivo and indicate that at least part of the pathogenetic TNF-alpha is T cell derived.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.