ArticleThe Journal of experimental medicine1993
p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells.
Article in The Journal of experimental medicine, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 139 citations in OpenAlex.
- Using the Jurkat reporter T cell line for evaluating the functionality of novel chimeric antigen receptors.Frontiers in molecular medicine · 2023Article
- Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes.Frontiers in cell and developmental biology · 2021Article
- Genetic alterations affecting GTPases and T-cell receptor signaling in peripheral T-cell lymphomas.Small GTPases · 2019Review
- TCR signal strength controls the differentiation of CD4Science immunology · 2018Article
- Epithelial calcineurin controls microbiota-dependent intestinal tumor development.Nature medicine · 2016Article
- Distinct Roles of Cytoskeletal Components in Immunological Synapse Formation and Directed Secretion.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The disease-linked Glu-26-Lys mutant version of Coronin 1A exhibits pleiotropic and pathway-specific signaling defects.Molecular biology of the cell · 2015Article
- Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation.The EMBO journal · 2011Article
- Serum calcium-decreasing factor, caldecrin, inhibits osteoclast differentiation by suppression of NFATc1 activity.The Journal of biological chemistry · 2010Article
- Primers on molecular pathways--the NFAT transcription pathway in pancreatic cancer.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2010Review
- RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses.Molecular and cellular biology · 2007Article
- Inhibition of lymphocyte activation and function by the prenylation inhibitor L-778,123.Investigational new drugs · 2005Article
- T-cell antigen receptor signal transduction.Immunology · 2002Article
- Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling.The Journal of experimental medicine · 2001Article
- Schiff base-mediated co-stimulation primes the T-cell-receptor-dependent calcium signalling pathway in CD4 T cells.Immunology · 2001Article
- Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT.Molecular and cellular biology · 2001Article
- Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation.Molecular and cellular biology · 2001Article
- Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT).Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes.Molecular and cellular biology · 1999Article
- A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK.The EMBO journal · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In T lymphocytes, triggering of the T cell receptor (TCR) induces several signaling cascades which ultimately synergize to induce the activity of the nuclear factor of activated T cells (NFAT), a DNA binding complex critical to the inducibility and T cell specificity of the T cell growth factor interleukin 2. One immediate consequence of T cell activation via the TCR is an increase in cytosolic calcium. Calcium signals are important for NFAT induction, and recent studies have identified calcineurin, a calcium-calmodulin dependent serine-threonine phosphatase, as a prominent component of the calcium signaling pathway in T cells. A second important molecule in TCR signal transduction is the guanine nucleotide binding protein, p21ras, which is coupled to the TCR by a protein tyrosine kinase dependent mechanism. The experiments presented here show that expression by transfection of mutationally activated calcineurin or activated p21ras alone is insufficient for NFAT transactivation. However, coexpression of the activated calcineurin with activated p21ras could mimic TCR signals in NFAT induction. These data identify calcineurin and p21ras as cooperative partners in T cell activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.