ArticleThe Journal of clinical investigation1993
Different localization and regulation of two types of vasopressin receptor messenger RNA in microdissected rat nephron segments using reverse transcription polymerase chain reaction.
Article in The Journal of clinical investigation, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 134 citations in OpenAlex.
- Novel Roles of GPCRs in the Renal Collecting Duct.Physiology (Bethesda, Md.) · 2026Review
- Metabolically stable apelin analogs: development and functional role in water balance and cardiovascular function.Clinical science (London, England : 1979) · 2025Review
- Effect of Pituitary-Target Gland Axis on RAAS in the Context of COVID-19.International journal of medical sciences · 2025Review
- Metabolic effects of vasopressin in pathophysiology of diabetic kidney disease.Frontiers in endocrinology · 2023Review
- Terlipressin combined with conservative fluid management attenuates hemorrhagic shock-induced acute kidney injury in rats.Scientific reports · 2022Article
- Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation.International journal of molecular sciences · 2021Review
- Stimulation of V1a receptor increases renal uric acid clearance via urate transporters: insight into pathogenesis of hypouricemia in SIADH.Clinical and experimental nephrology · 2016Article
- Copeptin is associated with kidney length, renal function, and prevalence of simple cysts in a population-based study.Journal of the American Society of Nephrology : JASN · 2015Article
- Role of collecting duct endothelin in control of renal function and blood pressure.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Review
- Lithium: a versatile tool for understanding renal physiology.American journal of physiology. Renal physiology · 2013Review
- Vasopressin: a novel target for the prevention and retardation of kidney disease?Nature reviews. Nephrology · 2013Review
- Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC.The American journal of pathology · 2013Article
- Physiology of endothelin and the kidney.Comprehensive Physiology · 2011Review
- Regulation of blood pressure and salt homeostasis by endothelin.Physiological reviews · 2011Review
- Vasopressin in chronic kidney disease: an elephant in the room?Kidney international · 2009Article
- Tolvaptan, a selective oral vasopressin V2 receptor antagonist, ameliorates podocyte injury in puromycin aminonucleoside nephrotic rats.Clinical and experimental nephrology · 2009Article
- Effects of the renal medullary pH and ionic environment on vasopressin binding and signaling.Kidney international · 2008Article
- Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium.Journal of the American Society of Nephrology : JASN · 2008Article
- Rat renal arcade segment expresses vasopressin-regulated water channel and vasopressin V2 receptor.The Journal of clinical investigation · 1996Article
- Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA.The Journal of clinical investigation · 1995Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have revealed that arginine vasopressin (AVP) has at least two types of receptors in the kidney: V1a receptor and V2 receptor. In this study, microlocalization of mRNA coding for V1a and V2 receptors was carried out in the rat kidney using a reverse transcription and polymerase chain reaction. Large signals for V1a receptor PCR product were detected in the glomerulus, initial cortical collecting duct, cortical collecting duct, outer medullary collecting duct, inner medullary collecting duct, and arcuate artery. Small but detectable signals were found in proximal convoluted and straight tubules, inner medullary thin limbs, and medullary thick ascending limbs. Large signals for V2 receptor mRNA were detected in the cortical collecting duct, outer medullary collecting duct, and inner medullary collecting duct. Small signals for V2 receptor were found in the inner medullary thick limbs, medullary thick ascending limbs, and initial cortical collecting duct. Next, we investigated V1a and V2 receptor mRNA regulation in the dehydrated state. During a 72-h water restriction state, the plasma AVP level increased and V2 receptor mRNA decreased in collecting ducts. In contrast, V1a receptor mRNA did not change significantly. Thus, the two AVP receptor subtypes are distributed differently along the nephron, and these mRNAs are regulated differently in the dehydrated state.
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