ArticleThe Journal of clinical investigation1993
Tissue-specific expression of the gene coding for human Clara cell 10-kD protein, a phospholipase A2-inhibitory protein.
Article in The Journal of clinical investigation, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- Intratracheal Clara cell secretory protein (CCSP) administration in preterm infants with or at risk of respiratory distress syndrome.The Cochrane database of systematic reviews · 2011Pooled it
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- TRIM58/cg26157385 methylation is associated with eight prognostic genes in lung squamous cell carcinoma.Oncology reports · 2018Article
- Uteroglobin gene polymorphism (G38A) may be a risk factor in childhood idiopathic nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2018Article
- Gene expression profile changes in the jejunum of weaned piglets after oral administration of Lactobacillus or an antibiotic.Scientific reports · 2017Article
- Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD).Expert opinion on therapeutic targets · 2016Review
- Uteroglobin, a possible ligand of the lipoxin receptor inhibits serum amyloid A-driven inflammation.Mediators of inflammation · 2014Article
- Identification of novel tissue-specific genes by analysis of microarray databases: a human and mouse model.PloS one · 2013Article
- Multiple secretoglobin 1A1 genes are differentially expressed in horses.BMC genomics · 2012Article
- Lack of an endogenous anti-inflammatory protein in mice enhances colonization of B16F10 melanoma cells in the lungs.The Journal of biological chemistry · 2010Article
- CC16 inhibits the migration of eosinophils towards the formyl peptide fMLF but not towards PGD2.Inflammation · 2009Article
- Serum biomarkers in interstitial lung diseases.Respiratory research · 2005Review
- Inhibitory effect of adenovirus-uteroglobin transduction on the growth of lung cancer cell lines.Cancer gene therapy · 2003Article
- Uteroglobin promoter-targeted c-MYC expression in transgenic mice cause hyperplasia of Clara cells and malignant transformation of T-lymphoblasts and tubular epithelial cells.Transgenic research · 2001Article
- Loss of transformed phenotype in cancer cells by overexpression of the uteroglobin gene.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Potential roles of osteopontin and alphaVbeta3 integrin in the development of coronary artery restenosis after angioplasty.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clara cell 10-kD protein (cc10kD), a secretory phospholipase A2 inhibitor, is suggested to be the human counterpart of rabbit uteroglobin (UG). Because cc10kD is expressed constitutively at a very high level in the human respiratory epithelium, the 5' region of its gene may be useful in achieving organ-specific expression of recombinant DNA in gene therapy of diseases such as cystic fibrosis. However, it is important to establish the tissue-specific expression of this gene before designing gene transfer experiments. Since the UG gene in the rabbit is expressed in many other organs besides the lung and the endometrium, we investigated the organ and tissue specificity of human cc10kD gene expression using polymerase chain reaction, nucleotide sequence analysis, immunofluorescence, and Northern blotting. Our results indicate that, in addition to the lung, cc10kD is expressed in several nonrespiratory organs, with a distribution pattern very similar, if not identical, to that of UG in the rabbit. These results underscore the necessity for more detailed analyses of the 5' region of the human cc10kD gene before its usefulness in gene therapy could be fully assessed. These data also suggest that cc10kD and UG may have similar physiological function(s).
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