ArticleThe Journal of cell biology1993
Accumulation of actin in subsets of pioneer growth cone filopodia in response to neural and epithelial guidance cues in situ.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 128 citations in OpenAlex.
- Abnormal cytoskeletal remodeling but normal neuronal excitability in a mouse model of the recurrent developmental and epileptic encephalopathy-susceptibility KCNB1-p.R312H variant.Communications biology · 2024Article
- A new view of axon growth and guidance grounded in the stochastic dynamics of actin networks.Open biology · 2023Article
- Dynamic morphogenesis of a pioneer axon inMolecular biology of the cell · 2020Article
- Complexes formed with integrin-α5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticityFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Article
- A single tyrosine phosphorylation site in cortactin is important for filopodia formation in neuronal growth cones.Molecular biology of the cell · 2019Article
- A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways.Neural plasticity · 2019Review
- Opposing Morphogenetic Defects on Dendrites and Mossy Fibers of Dentate Granular Neurons in CRMP3-Deficient Mice.Brain sciences · 2018Article
- A low-cost microwell device for high-resolution imaging of neurite outgrowth in 3D.Journal of neural engineering · 2018Article
- SYD-1 Promotes Multiple Developmental Steps Leading to Neuronal Connectivity.Molecular neurobiology · 2016Review
- Cytoskeletal social networking in the growth cone: How +TIPs mediate microtubule-actin cross-linking to drive axon outgrowth and guidance.Cytoskeleton (Hoboken, N.J.) · 2016Review
- A novel role for doublecortin and doublecortin-like kinase in regulating growth cone microtubules.Human molecular genetics · 2012Article
- Multiple effects of electroporation on the adhesive behaviour of breast cancer cells and fibroblasts.Cancer cell international · 2012Article
- MIG-10 functions with ABI-1 to mediate the UNC-6 and SLT-1 axon guidance signaling pathways.PLoS genetics · 2012Article
- Activation of ADF/cofilin mediates attractive growth cone turning toward nerve growth factor and netrin-1.Developmental neurobiology · 2010Article
- Topography and nanomechanics of live neuronal growth cones analyzed by atomic force microscopy.Biophysical journal · 2009Article
- Axon guidance: asymmetric signaling orients polarized outgrowth.Trends in cell biology · 2008Review
- Quantitative analysis of microtubule dynamics during adhesion-mediated growth cone guidance.Developmental neurobiology · 2008Article
- CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin.Current biology : CB · 2008Article
- CRMP3 is required for hippocampal CA1 dendritic organization and plasticity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Directed outgrowth of neural processes must involve transmission of signals from the tips of filopodia to the central region of the growth cone. Here, we report on the distribution and dynamics of one possible element in this process, actin, in live growth cones which are reorienting in response to in situ guidance cues. In grasshopper embryonic limbs, pioneer growth cones respond to at least three types of guidance cues: a limb axis cue, intermediate target cells, and a circumferential band of epithelial cells. With time-lapse imaging of intracellularly injected rhodamine-phalloidin and rhodamine-actin, we monitored the distribution of actin during growth cone responses to these cues. In distal limb regions, accumulation of actin in filopodia and growth cone branches accompanies continued growth, while reduction of actin accompanies withdrawal. Where growth cones are reorienting to intermediate target cells, or along the circumferential epithelial band, actin selectively accumulates in the proximal regions of those filopodia that have contacted target cells or are extending along the band. Actin accumulations can be retrogradely transported along filopodia, and can extend into the central region of the growth cone. These results suggest that regulation and translocation of actin may be a significant element in growth cone steering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.