Evidence map›Paper›PMID 8224817›Full record

ArticleGenetics1993

Molecular and genetic analysis of the SNF7 gene in Saccharomyces cerevisiae.

J Tu, L G Vallier, M Carlson

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 38 citations in OpenAlex.

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  16. A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR).Proceedings of the National Academy of Sciences of the United States of America · 2000
    Article
  17. Article
  18. Article
  19. Yeast carbon catabolite repression.Microbiology and molecular biology reviews : MMBR · 1998
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

J TuInstitute of Cancer Research, Columbia University, New York, New York 10032.
L G Vallier
M Carlson
Columbia University · US

Funding

REGULATION OF YEAST INVERTASE GENE EXPRESSIONR37GM034095 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CARLSON, MARIAN B · 1996 to 2005
$3.1M
REGULATION OF YEAST INVERTASE GENE EXPRESSIONR01GM034095 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CARLSON, MARIAN B · 1985 to 2014
$2.9M
NIGMS NIH HHS GM34095
6 · The paper itself

Abstract

Mutations in the SNF7 gene of Saccharomyces cerevisiae prevent full derepression of the SUC2 (invertase) gene in response to glucose limitation. We report the molecular cloning of the SNF7 gene by complementation. Sequence analysis predicts that the gene product is a 27-kDa acidic protein. Disruption of the chromosomal locus causes a fewfold decrease in invertase derepression, a growth defect on raffinose, temperature-sensitive growth on glucose, and a sporulation defect in homozygous diploids. Genetic analysis of the interactions of the snf7 null mutation with ssn6 and spt6/ssn20 suppressor mutations distinguished SNF7 from the SNF2, SNF5 and SNF6 genes. The snf7 mutation also behaved differently from mutations in SNF1 and SNF4 in that snf7 ssn6 double mutants displayed a synthetic phenotype of severe temperature sensitivity for growth. We also mapped SNF7 to the right arm of chromosome XII near the centromere.

Indexed as

Genes, FungalNuclear ProteinsSaccharomyces cerevisiae ProteinsAmino Acid SequenceBase Sequencebeta-FructofuranosidaseChromosome MappingChromosomes, FungalCloning, MolecularDNA, RecombinantEndosomal Sorting Complexes Required for TransportEscherichia coliFungal ProteinsGene Expression Regulation, FungalGenes, SuppressorGlucosebeta-FructofuranosidaseDNA, RecombinantEndosomal Sorting Complexes Required for TransportFungal ProteinsGlucoseGlycoside HydrolasesNuclear ProteinsSaccharomyces cerevisiae ProteinsSNF7 protein, S cerevisiae

Identifiers

PMID8224817
PMCPMC1205616
OpenAlexW2150285114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.