ArticleExperimental brain research1993
Pharmacologic characterization of opioid peptide release from chromaffin cell transplants using a brain slice superfusion method.
Article in Experimental brain research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 14 citations in OpenAlex.
- Review of the history and current status of cell-transplant approaches for the management of neuropathic pain.Pain research and treatment · 2012Article
- Pharmacologic specificity of antidepressive activity by monoaminergic neural transplants.Psychopharmacology · 1995Article
- Chromaffin cell xenografts in the rat neocortex can produce antidepressive activity in the forced swimming test.Experimental brain research · 1995Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
A simple chamber and an inexpensive superfusion system for studying mammalian brain slices containing neural transplants is described. With this method, rat brain slices containing bovine chromaffin cell transplants can be maintained for several hours, allowing for the determination of neurochemical characteristics and pharmacologic responsiveness of the grafted cells. Using this technique, basal and nicotine-stimulated release of metenkephalin from rat periaqueductal gray slices containing bovine chromaffin cell transplants were measured. Results showed that met-enkephalin release can be increased by nicotinic stimulation in slices containing chromaffin cell, but not control implants, for at least 8 weeks postimplantation. Furthermore, this response was dose-related. These results are in good agreement with previous behavioral studies and provide corroborative evidence for the mechanism of pain reduction by the release of opioid peptides from chromaffin cell transplants in the periaqueductal gray. This study demonstrates that neurochemical and pharmacologic analyses of neural transplants using a superfused brain slice method can be a complementary approach in determining the underlying mechanisms of neural transplants in the central nervous system.
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Registered trials
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