ArticleThe EMBO journal1993
TCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity on V(D)J recombination events.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Lineage- and stage-specific activity of antigen receptor gene enhancers during lymphocyte development.Frontiers in epigenetics and epigenomics · 2024Review
- Helix-Loop-Helix Proteins in Adaptive Immune Development.Frontiers in immunology · 2022Review
- Characterization of transcripts emanating from enhancer Eβ of the murine TCRβ locus.FEBS open bio · 2021Article
- Access Guide to Antigen Receptor Genes.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'.Immunology · 2013Review
- H3K4 tri-methylation provides an epigenetic signature of active enhancers.The EMBO journal · 2011Article
- Differential utilization of T cell receptor TCR alpha/TCR delta locus variable region gene segments is mediated by accessibility.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Activation of 12/23-RSS-dependent RAG cleavage by hSWI/SNF complex in the absence of transcription.Molecular cell · 2008Article
- Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion.The EMBO journal · 2007Article
- SMAR1 and Cux/CDP modulate chromatin and act as negative regulators of the TCRbeta enhancer (Ebeta).Nucleic acids research · 2004Article
- Stepwise activation of the immunoglobulin mu heavy chain gene locus.The EMBO journal · 2001Article
- V(D)J recombination is not activated by demethylation of the kappa locus.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- TCRalpha enhancer activation occurs via a conformational change of a pre-assembled nucleo-protein complex.The EMBO journal · 2000Article
- Definition of a T-cell receptor beta gene core enhancer of V(D)J recombination by transgenic mapping.Molecular and cellular biology · 2000Article
- A novel element upstream of the Vgamma2 gene in the murine T cell receptor gamma locus cooperates with the 3' enhancer to act as a locus control region.The Journal of experimental medicine · 1999Article
- Regulation of V(D)J recombination by transcriptional promoters.Molecular and cellular biology · 1999Article
- Positive and negative regulation of V(D)J recombination by the E2A proteins.The Journal of experimental medicine · 1999Article
- Warner-Lambert/Parke-Davis Award Lecture. Pathological and physiological double-strand breaks: roles in cancer, aging, and the immune system.The American journal of pathology · 1998Review
- Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Kappa chain monoallelic demethylation and the establishment of allelic exclusion.Genes & development · 1998Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe transgenic mice carrying germline variable gene segments associated with either the T cell receptor (TCR) beta or alpha gene enhancers (E beta or E alpha). Transgenic constructs underwent high rates of site-specific rearrangements predominantly in T cells from independent mice. Rearrangements of the E beta-containing transgenes began at different stages of T cell differentiation in embryonic and adult thymus than did the E alpha-containing ones, with a pattern superimposable upon the patterns of TCR beta or TCR alpha gene expression, respectively. We demonstrate that sequences within the TCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity upon the V(D)J recombination events affecting adjacent gene segments. The patterns of transgene expression also gave information on developmental events and lineage relationships (gamma delta versus alpha beta) during T cell development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.