ArticleThe EMBO journal1993
The activity of S.pombe DSC-1-like factor is cell cycle regulated and dependent on the activity of p34cdc2.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Nrm1 is a bistable switch connecting cell cycle progression to transcriptional control.EMBO reports · 2025Article
- Cyclin-dependent kinases: Masters of the eukaryotic universe.Wiley interdisciplinary reviews. RNA · 2023Review
- Computational modeling of chromosome re-replication in mutant strains of fission yeast.Molecular biology of the cell · 2021Article
- Down-regulation of Cdk1 activity in G1 coordinates the G1/S gene expression programme with genome replication.Current genetics · 2019Review
- A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast.Molecular and cellular biology · 2009Article
- A role for the START gene-specific transcription factor complex in the inactivation of cyclin B and Cut2 destruction.Molecular biology of the cell · 2000Article
- A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast.Molecular biology of the cell · 2000Article
- Cell cycle-regulated transcription in fission yeast: Cdc10-Res protein interactions during the cell cycle and domains required for regulated transcription.Molecular biology of the cell · 1999Article
- Functional domains of rep2, a transcriptional activator subunit for Res2-Cdc10, controlling the cell cycle "start".Molecular biology of the cell · 1998Article
- The fission yeast protein p73res2 is an essential component of the mitotic MBF complex and a master regulator of meiosis.Molecular and cellular biology · 1997Article
- Control of S-phase periodic transcription in the fission yeast mitotic cycle.The EMBO journal · 1997Article
- Ran1 functions to control the Cdc10/Sct1 complex through Puc1.Molecular biology of the cell · 1997Article
- The Cdc2 protein kinase controls Cdc10/Sct1 complex formation.Molecular biology of the cell · 1997Article
- Functional characterization of the fission yeast Start-specific transcription factor Res2.The EMBO journal · 1997Article
- Fission yeast pheromone blocks S-phase by inhibiting the G1 cyclin B-p34cdc2 kinase.The EMBO journal · 1997Article
- Domains determining the functional distinction of the fission yeast cell cycle "start" molecules Res1 and Res2.Molecular biology of the cell · 1996Article
- Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe.Molecular and cellular biology · 1996Article
- cdc18+ regulates initiation of DNA replication in Schizosaccharomyces pombe.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Binding to the yeast SwI4,6-dependent cell cycle box, CACGAAA, is cell cycle regulated in vivo.Nucleic acids research · 1996Article
- Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the eukaryotic cell cycle, there are major control points in late G2 to determine the timing of the initiation of mitosis, and in late G1, regulating entry into S phase. In yeasts, this latter control is called start. Traverse of the start control and progression to S phase is accompanied by an increase in the expression of some of the genes whose products are required for DNA synthesis. In Saccharomyces cerevisiae, the coordinate expression of these genes in late G1 is dependent on a cis-acting sequence element called the MluI cell cycle box (MCB). A transcription factor called DSC-1 binds these elements and mediates cell cycle regulated transcription, though it is unclear whether this is by cell cycle-dependent changes in its activity. A DSC-1-like factor has also been identified in the fission yeast S.pombe. This is composed of at least the products of the cdc10 and sct1/res1 genes, and binds to the promoters of genes whose expression increases prior to S phase. We demonstrate that p85cdc10 is a nuclear protein and that the activity of the S.pombe DSC-1 factor varies through the cell cycle; it is high in cells that have passed start, decreases at the time of anaphase, remains low during the pre-start phase of G1 and increases at the time of the next S phase. We also show that the reactivation in late G1 is dependent on the G1 form of p34cdc2.
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