Trial reportArchives of disease in childhood1993
Use of budesonide in severe asthmatics aged 1-3 years.
Trial report in Archives of disease in childhood, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Budesonide for chronic asthma in children and adults.The Cochrane database of systematic reviews · 2001Pooled it
- Inhaled steroids for episodic viral wheeze of childhood.The Cochrane database of systematic reviews · 2000Pooled it
- Signs and symptoms that precede wheezing in children with a pattern of moderate-to-severe intermittent wheezing.The Journal of pediatrics · 2009Trial
- Randomised controlled study of clinical efficacy of spacer therapy in asthma with regard to electrostatic charge.Archives of disease in childhood · 2001Trial
- The effects of inhaled beclomethasone dipropionate on lung function and histamine responsiveness in recurrently wheezy infants.Archives of disease in childhood · 1995Trial
- A non-electrostatic spacer for aerosol delivery.Archives of disease in childhood · 1995Trial
- Budesonide. An appraisal of the basis of its pharmacoeconomic and quality-of-life benefits in asthma.PharmacoEconomics · 1995Trial
- Effect of continuous treatment with topical corticosteroid on episodic viral wheeze in preschool children.Archives of disease in childhood · 1995Trial
- Overweight/obesity status in preschool children associates with worse asthma but robust improvement on inhaled corticosteroids.The Journal of allergy and clinical immunology · 2018Article
- The Bioavailability of Salbutamol in Urine via Volumatic and Nonvolumatic Valved Holding Chambers.The World Allergy Organization journal · 2011Article
- The use of inhaled corticosteroids in children with asthma.Current allergy and asthma reports · 2002Review
- Review
- Nebuliser therapy in childhood.Thorax · 1997Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The treatment of severe asthmatics aged 1-3 years with budesonide administered via Nebuhaler and Laerdal facemask was assessed in a six month, double blind, placebo controlled study. Patients were randomised to budesonide (n = 20) or placebo (n = 20) treatment. Daily symptom scores were recorded by parents and clinic visits occurred every six weeks. Cough scores improved significantly with budesonide: nocturnal and daytime cough scores (0-2) fell by a mean (SEM) of 0.4 (0.2) and 0.5 (0.2); while with placebo the nocturnal score increased by 0.1 (0.2) and daytime score was unchanged at 0.0 (0.2). All other data showed improvements for active over placebo treatment. Thirteen children in each group completed six months' treatment. Parents of 25 of these found the delivery system convenient and easy to use. While blinded to treatment it was assessed to be beneficial in nine of 13 receiving budesonide and four of 13 receiving placebo. The Nebuhaler and facemask is an acceptable delivery system for long term asthma treatment. Symptoms are significantly reduced when it is used to give 400-800 micrograms budesonide/day to children aged 1-3 years who cannot use other delivery systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.