Evidence map›Paper›PMID 8215290›Full record

ArticleAntimicrobial agents and chemotherapy1993

In vivo effects of rufloxacin and ciprofloxacin on T-cell subsets and tumor necrosis factor production in mice infected with Bacteroides fragilis.

S V Gollapudi, S K Chuah, T Harvey, H D Thadepalli, H Thadepalli

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Biliary excretion of rufloxacin in humans.Antimicrobial agents and chemotherapy · 1993
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

S V GollapudiDepartment of Internal Medicine, Charles R. Drew University of Medicine and Science, UCLA School of Medicine 90059.
S K Chuah
T Harvey
H D Thadepalli
H Thadepalli
Charles R. Drew University of Medicine and Science · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the in vivo effects of rufloxacin and ciprofloxacin on T-cell subsets and tumor necrosis factor production in mice infected with Bacteroides fragilis. These quinolones did not alter the helper/suppressor ratio but did modulate the kinetics of tumor necrosis factor production in infected animals. This result correlated with the observed therapeutic efficacies of the quinolones.

Indexed as

Bacteroides fragilisFluoroquinolonesAnimalsAnti-Infective AgentsBacteroides InfectionsCD4-CD8 RatioCell DivisionCiprofloxacinFemaleMiceMice, Inbred C3HOrgan SizeQuinolonesSpleenT-LymphocytesT-Lymphocyte SubsetsAnti-Infective AgentsCiprofloxacinFluoroquinolonesQuinolonesrufloxacinTumor Necrosis Factor-alpha

Identifiers

PMID8215290
PMCPMC188049
OpenAlexW1984631439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.