ArticleThe American journal of pathology1993
Localization of dystrophin and beta-spectrin in vacuolar myopathies.
Article in The American journal of pathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 46 citations in OpenAlex.
- Repeat Expansions in PLIN4 Cause Autosomal Dominant Vacuolar Myopathy With Sarcolemmal Features.Annals of clinical and translational neurology · 2025Article
- Autophagic vacuolar pathology in desminopathies.Neuromuscular disorders : NMD · 2015Article
- Autophagy and mitochondria in Pompe disease: nothing is so new as what has long been forgotten.American journal of medical genetics. Part C, Seminars in medical genetics · 2012Review
- Generalized lysosome-associated membrane protein-2 defect explains multisystem clinical involvement and allows leukocyte diagnostic screening in Danon disease.The American journal of pathology · 2006Article
- Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19.Molecular biology of the cell · 2005Article
- The spectrin skeleton of newly-invaginated plasma membrane.Journal of muscle research and cell motility · 2000Article
- Accessibility of T-tubule vacuoles to extracellular dextran and DNA: mechanism and potential application of vacuolation.Journal of muscle research and cell motility · 1998Article
- Immunocytochemical study of CD45 T cell isoforms in inflammatory myopathies.The American journal of pathology · 1995Article
- Discrete and reversible vacuole-like dilations induced by osmomechanical perturbation of neurons.The Journal of membrane biology · 1995Article
- Ultrastructural localization of the C-terminus of the 43-kd dystrophin-associated glycoprotein and its relation to dystrophin in normal murine skeletal myofiber.The American journal of pathology · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We examined the expression of the cytoskeletal proteins dystrophin and beta-spectrin on vacuolar boundaries in vacuolar myopathies. We also localized utrophin, a dystrophin homologue, and laminin, which served as a marker for the basal lamina. Four types of vacuoles were identified. Type 1 vacuoles, found in all diseases, were lined by laminin, dystrophin, and beta-spectrin and arose from infoldings of the basal lamina and sarcolemma into splitting or branching fibers. Type 2 vacuoles were lined by dystrophin and beta-spectrin and were most common in adult acid maltase deficiency, chloroquine myopathy, and periodic paralysis. Traces of utrophin were also noted on the boundaries of some type 2 vacuoles, but only in those fibers that also expressed utrophin on their surface membrane. Type 3 vacuoles were lined by small patches of dystrophin and beta-spectrin and occurred in any vacuolar myopathy. Type 4 vacuoles were unlined by any of the above antigens and were most common in infantile acid maltase deficiency and in the nonlysosomal glycogenoses. Immunoelectron microscopy confirmed the dystrophin label on vacuolar boundaries but revealed no reaction product on any other membranous component within the muscle fiber. We conclude that dystrophin and beta-spectrin provide cytoskeletal support for a species of membrane-bound vacuoles in diverse myopathies.
Indexed as
Identifiers
8214011PMC1887052W1710586963What OpenQuestion holds
Registered trials
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