ArticleThe American journal of pathology1993
Polymorphonuclear leukocytes as a significant source of tumor necrosis factor-alpha in endotoxin-challenged lung tissue.
Article in The American journal of pathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 104 citations in OpenAlex.
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- Treatment Effects of Jinlingzi Powder and Its Extractive Components on Gastric Ulcer Induced by Acetic Acid in Rats.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- The tyrosine kinase inhibitor imatinib prevents lung injury and death after intravenous LPS in mice.Physiological reports · 2015Article
- Neutrophil dependence of vascular remodeling after Mycoplasma infection of mouse airways.The American journal of pathology · 2014Article
- Regulation of TB vaccine-induced airway luminal T cells by respiratory exposure to endotoxin.PloS one · 2012Article
- Troglitazone-activated PPARγ inhibits LPS-induced lung alveolar type II epithelial cells injuries via TNF-α.Molecular biology reports · 2011Article
- Protease-activated receptor 2 deficiency reduces cardiac ischemia/reperfusion injury.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- Inhaled nitric oxide alleviates hyperoxia suppressed phosphatidylcholine synthesis in endotoxin-induced injury in mature rat lungs.Respiratory research · 2006Article
- Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury.Respiratory research · 2005Article
- Role for macrophage inflammatory protein 2 (MIP-2), MIP-1alpha, and interleukin-1alpha in the delayed-type hypersensitivity response to viral antigen.Journal of virology · 2002Article
- Neutrophil interaction with inflamed postcapillary venule endothelium alters annexin 1 expression.The American journal of pathology · 2001Article
- Role of polymorphonuclear neutrophils in a murine model of Chlamydia psittaci-induced abortion.Infection and immunity · 1999Article
- Epidermal growth factor system regulates mucin production in airways.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Intratracheal instillation versus intratracheal inhalation: influence of cytokines on inflammatory response.Environmental health perspectives · 1997Article
- Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-beta 1 and myofibroblast accumulation.The American journal of pathology · 1997Article
- Effect of tumor necrosis factor receptor binding protein on cell infiltration induced by lipopolysaccharide and Sephadex beads in guinea pig lung.Inflammation · 1995Article
- Role of endotoxin in acute inflammation induced by gram-negative bacteria: specific inhibition of lipopolysaccharide-mediated responses with an amino-terminal fragment of bactericidal/permeability-increasing protein.Infection and immunity · 1995Article
- Acute inflammation causes epithelial invasion and mucosal destruction in experimental shigellosis.The Journal of experimental medicine · 1994Article
- Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils.The Journal of experimental medicine · 1994Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kinetic expression and potential cellular source of tumor necrosis factor-alpha (TNF-alpha) in lipopolysaccharide-(LPS) induced acute lung inflammation was investigated using a rat model by Northern blot analysis, in situ hybridization and immunohistochemistry. LPS induced a polymorphonuclear leukocyte infiltrate in the lung that peaked between 6 and 24 hours. TNF-alpha messenger (m)RNA was strongly induced by LPS in whole lung tissues shown by Northern analysis. Both alveolar macrophages and polymorphonuclear leukocytes (PMNs), purified from bronchoalveolar lavage fluids of LPS-treated rats, were shown to express TNF-alpha mRNA by Northern analysis. However, PMNs displayed several times more TNF-alpha mRNA, relative to actin mRNA, than alveolar macrophages at 6 and 12 hours. By in situ hybridization, most of the cells positive for TNF-alpha mRNA at 6 and 12 hours seemed to be PMNs located within the tissue near bronchioles or vessels. By immunohistochemistry, TNF-alpha protein was localized mainly to alveolar macrophages at early times (1 to 3 hours) after LPS challenge, and thereafter, PMNs seemed to be the predominant source of TNF-alpha protein as more than 90% of total intraalveolar positive cells at 6 and 12 hours were PMN. Thus, our data provide the first in vivo evidence that PMNs can serve as a significant source of TNF-alpha at sites of acute inflammation.
Indexed as
Identifiers
8213996PMC1887070W73625371What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.