ArticleThe American journal of pathology1993
Expression of osteopontin messenger RNA by macrophages in atherosclerotic plaques. A possible association with calcification.
Article in The American journal of pathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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Who cites it
55 citing papers in PubMed, 257 citations in OpenAlex.
- Role of Matricellular Proteins in Endothelial Cell Inflammation and Atherosclerosis.Antioxidants (Basel, Switzerland) · 2025Review
- Osteoprotegerin as an Emerging Biomarker of Carotid Artery Stenosis? A Scoping Review with Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- Calcified plaque harboring lipidic materials associates with no-reflow phenomenon after PCI in stable CAD.The international journal of cardiovascular imaging · 2023Observational
- Matricellular proteins in atherosclerosis development.Matrix biology : journal of the International Society for Matrix Biology · 2023Review
- Missing Teeth as an Early Predictive "Sign" for Atherosclerosis: A Retrospective Study.ARYA atherosclerosis · 2022Article
- Osteopontin - The stirring multifunctional regulatory factor in multisystem aging.Frontiers in endocrinology · 2022Review
- Pulp Stones: Diagnostic Significance in Early Diagnosis and Radiographic Correlation with Ischemic Heart Diseases.The Indian journal of radiology & imaging · 2021Article
- The Relationship Between Carotid Intima Media Thickness, Inflammation and GLA Rich Protein Levels in Chronic Kidney Disease.International journal of general medicine · 2021Article
- The Influence of Calcification Factors and Endothelial-Dysfunction Factors on the Development of Unstable Atherosclerotic Plaques.Diagnostics (Basel, Switzerland) · 2020Article
- Roles of Histone Acetylation Modifiers and Other Epigenetic Regulators in Vascular Calcification.International journal of molecular sciences · 2020Review
- The Regulation of Exosome-Derived miRNA on Heterogeneity of Macrophages in Atherosclerotic Plaques.Frontiers in immunology · 2020Article
- Bone Morphogenetic Protein-2 and Osteopontin Gene Expression in Epicardial Adipose Tissue from Patients with Coronary Artery Disease Is Associated with the Presence of Calcified Atherosclerotic Plaques.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Osteopontin for Early Detection of Microvascular and Macrovascular Type 1 Diabetic Complication.Open access Macedonian journal of medical sciences · 2019Article
- The rs1126616 Single Nucleotide Polymorphism of the Osteopontin Gene Is Independently Associated with Cardiovascular Events in a Chronic Kidney Disease Cohort.Journal of clinical medicine · 2019Article
- Genetics of Subclinical Coronary Atherosclerosis.Current genetic medicine reports · 2018Article
- Correlation between Pulp Stones and Gall Bladder Stones: A Radiographic Retrospective Case-Control Study.Contemporary clinical dentistry · 2018Article
- Differential expression of osteopontin, and osteoprotegerin mRNA in epicardial adipose tissue between patients with severe coronary artery disease and aortic valvular stenosis: association with HDL subclasses.Lipids in health and disease · 2017Article
- Intracranial Artery Calcification and Its Clinical Significance.Journal of clinical neurology (Seoul, Korea) · 2016Review
- Osteopontin is elevated in patients with mitral annulus calcification independent from classic cardiovascular risk factors.BMC cardiovascular disorders · 2016Article
- Large animal models of cardiovascular disease.Cell biochemistry and function · 2016Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcification is a common complication in atherosclerosis. As osteopontin (OPN) and osteonectin (ON) are not only involved in the physiological but also the pathological calcification of tissues, we examined the expression of OPN and ON messenger (m)RNAs in normal and atherosclerotic human aortas. By Northern blotting, the OPN mRNA expression was related to the severity of the atherosclerosis. However, ON mRNA expression decreased with the development of atherosclerosis. By a combination of in situ hybridization and immunohistochemistry of serial sections, the macrophages surrounding the atheromatous plaques were identified as the OPN mRNA-expressing cells. The ON mRNA-expressing cells in aortas of a newborn baby and a 3-year-old boy were medial smooth muscle cells, but in aortas of adults, smooth muscle cells that had invaded the intima were found to express ON mRNA. As OPN mRNA-expressing macrophages surrounded the atheromatous plaques, and as the level of OPN mRNA expression increased as atherosclerosis advanced, it is possible that OPN plays a role in the calcification of atheromatous plaques.
Indexed as
Identifiers
8213995PMC1887054W1555422735What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.