Further evidence of a relationship between the retinoic acid receptor alpha locus and nonsyndromic cleft lip with or without cleft palate (CL +/- P)

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

12 citing papers in PubMed.

1. Role of carotenoids and retinoids during heart development.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020
   Review
2. Copy Number Changes Identified Using Whole Exome Sequencing in Nonsyndromic Cleft Lip and Palate in a Honduran Population.Birth defects research · 2017
   Article
3. Analysis of microsatellite polymorphisms in South Indian patients with non syndromic cleft lip and palate.Balkan journal of medical genetics : BJMG · 2013
   Article
4. Systematic analysis of palatal transcriptome to identify cleft palate genes within TGFβ3-knockout mice alleles: RNA-Seq analysis of TGFβ3 Mice.BMC genomics · 2013
   Article
5. Nonsyndromic cleft lip and palate: CRISPLD genes and the folate gene pathway connection.Birth defects research. Part A, Clinical and molecular teratology · 2011
   Article
6. Wnt/beta-catenin signaling in oral tissue development and disease.Journal of dental research · 2010
   Review
7. Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice.Developmental dynamics : an official publication of the American Association of Anatomists · 2006
   Article
8. Progress toward discerning the genetics of cleft lip.Current opinion in pediatrics · 2005
   Review
9. The clf1 gene maps to a 2- to 3-cM region of distal mouse chromosome 11.Mammalian genome : official journal of the International Mammalian Genome Society · 1996
   Article
10. Face facts: genes, environment, and clefts.American journal of human genetics · 1995
    Article
11. The major locus for multifactorial nonsyndromic cleft lip maps to mouse chromosome 11.Mammalian genome : official journal of the International Mammalian Genome Society · 1995
    Article
12. Retinoic acid, GABA-ergic, and TGF-beta signaling systems are involved in human cleft palate fibroblast phenotype.Molecular medicine (Cambridge, Mass.)
    Article

Corrections and comments

• Comment on
  Cleft lip with or without cleft palate: associations with transforming growth factor alpha and retinoic acid receptor loci.1992

Authors and funding

4 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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