ReviewScience (New York, N.Y.)1994
Forward and reverse genetic approaches to behavior in the mouse.
Review in Science (New York, N.Y.), 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 251 citations in OpenAlex.
- Investigation of CLOCK rs1801260 Polymorphism of Circadian Genes in Schizophrenia Patients.The Eurasian journal of medicine · 2026Article
- Genetic mapping identifies Homer1 as a developmental modifier of attention.Nature neuroscience · 2026Article
- Forward and reverse genomic screens enhance the understanding of phenotypic variation in a large Chinese rhesus macaque cohort.Nature communications · 2025Article
- Multiplex generation and single-cell analysis of structural variants in mammalian genomes.Science (New York, N.Y.) · 2025Article
- An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Multiplex generation and single cell analysis of structural variants in a mammalian genome.bioRxiv : the preprint server for biology · 2024Article
- A missense mutation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Combined use of specific length amplified fragment sequencing (SLAF-seq) and bulked segregant analysis (BSA) for rapid identification of genes influencing fiber content of hemp (Cannabis sativa L.).BMC plant biology · 2022Article
- Characterization of single nucleotide polymorphisms for a forward genetics approach using genetic crosses in C57BL/6 and BALB/c substrains of mice.Experimental animals · 2022Article
- The 50th anniversary of the Konopka and Benzer 1971 paper in PNAS: "Clock Mutants ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Molecular Evolution of clock Genes in Vertebrates.Journal of molecular evolution · 2021Article
- Recent advances in activity-based probes (ABPs) and affinity-based probes (AChemical science · 2021Review
- Application of Next Generation Sequencing in Laboratory Medicine.Annals of laboratory medicine · 2021Review
- Tissue-specific FAH deficiency alters sleep-wake patterns and results in chronic tyrosinemia in mice.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Post-genomic behavioral genetics: From revolution to routine.Genes, brain, and behavior · 2018Review
- Article
- Progress in Genome Editing Technology and Its Application in Plants.Frontiers in plant science · 2017Review
- Next-generation mammalian genetics toward organism-level systems biology.NPJ systems biology and applications · 2017Review
- A mutagenesis-derivedMolecular vision · 2017Article
- Molecular components of the circadian clock in mammals.Diabetes, obesity & metabolism · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Modern molecular genetic and genomic approaches are revolutionizing the study of behavior in the mouse. "Reverse genetics" (from gene to phenotype) with targeted gene transfer provides a powerful tool to dissect behavior and has been used successfully to study the effects of null mutations in genes implicated in the regulation of long-term potentiation and spatial learning in mice. In addition, "forward genetics" (from phenotype to gene) with high-efficiency mutagenesis in the mouse can uncover unknown genes and has been used to isolate a behavioral mutant of the circadian system. With the recent availability of high-density genetic maps and physical mapping resources, positional cloning of virtually any mutation is now feasible in the mouse. Together, these approaches permit a molecular analysis of both known and previously unknown genes regulating behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.