ArticleVirchows Archiv : an international journal of pathology1994
Immunohistochemical evaluation of alpha-catenin expression in human gastric cancer.
Article in Virchows Archiv : an international journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 110 citations in OpenAlex.
- Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin.Journal of cell science · 2017Article
- Tumor infiltration pattern into the surrounding tissue has prognostic significance in advanced gastric cancer.Virchows Archiv : an international journal of pathology · 2015Article
- Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases.Diagnostic pathology · 2014Article
- A role for the age-dependent loss of α(E)-catenin in regulation of N-cadherin expression and cell migration.Physiological reports · 2014Article
- α(E)-catenin regulates BMP-7 expression and migration in renal epithelial cells.American journal of nephrology · 2014Article
- MicroRNA-21 inhibits Serpini1, a gene with novel tumour suppressive effects in gastric cancer.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2012Article
- AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion.The Journal of cell biology · 2010Article
- The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon Carcinoma.Gastroenterology research and practice · 2010Article
- Bench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis.Seminars in cancer biology · 2008Review
- Effects of Helicobacter pylori on the cadherin-catenin complex.Journal of clinical pathology · 2006Article
- Mechanisms inactivating the gene for E-cadherin in sporadic gastric carcinomas.World journal of gastroenterology · 2006Article
- Alpha-catenin: at the junction of intercellular adhesion and actin dynamics.Nature reviews. Molecular cell biology · 2004Review
- Expression of E-cadherin, alpha-catenin, and beta-catenin in the process of lymph node metastasis in oral squamous cell carcinoma.British journal of cancer · 2003Article
- Immunohistochemical analysis of E-cadherin, alpha-catenin, beta-catenin, gamma-catenin, and neural cell adhesion molecule (NCAM) in chordoma.Journal of clinical pathology · 2001Article
- Relationship between phenotypes of cell-function differentiation and pathobiological behavior of gastric carcinomas.World journal of gastroenterology · 2001Article
- Changes in E-cadherin associated with cytoplasmic molecules in well and poorly differentiated endometrial cancer.British journal of cancer · 2000Article
- Article
- Reduction in membranous expression of beta-catenin and increased cytoplasmic E-cadherin expression predict poor survival in gastric cancer.British journal of cancer · 1999Article
- Analysis of E-cadherin in diffuse-type gastric cancer using a mutation-specific monoclonal antibody.The American journal of pathology · 1999Article
- Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility.Oncogene · 1999Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
E-cadherin (E-cad) plays a major role in the maintenance of cell-cell adhesion in epithelial tissues, and impaired E-cad expression correlates with tumour invasion and metastasis. Alpha-catenin (alpha-cat), an undercoat protein of adherens junctions, binds to the cytoplasmic domain of E-cad and is essential for linking E-cad to actin-based cytoskeleton. We investigated E-cad and alpha-cat expression in 60 human gastric cancers immunohistochemically. The 60 gastric cancers were classified into 18 (30%) in which alpha-cat expression was preserved, and 42 (70%) reduced cases. The reduction of alpha-cat expression was significantly related to dedifferentiation, depth of invasion, infiltrative growth and lymph node metastasis. We also examined the co-expression of alpha-cat and E-cad. Seventeen (28%) tumours preserved both molecules [alpha-cat(+)/E-cad(+)] and 33 (55%) tumours reduced both [alpha-cat(-)/E-cad(-)], whereas 9 (15%) tumours exhibited alpha-cat(-)/E-cad(+). The frequency of lymph node metastasis in alpha-cat(-)/E-cad(+) tumour (67%) was significantly higher than that in alpha-cat(+)/E-cad(+) tumours (24%) and was close to that in alpha-cat(-)/E-cad(-) tumours (82%). The frequency of haematogenous liver metastasis in alpha-cat(-)/E-cad(+) tumours (44%) was significantly higher than that in alpha-cat(+)/E-cad(+) tumours (6%) or alpha-cat(-)/E-cad(-) tumours (9%). Thus, in all E-cad(+) tumours, the frequency of lymph node and liver metastasis was higher in alpha-cat(-) tumours than in alpha-cat(+) tumours. alpha-Cat expression is apparently better at predicting tumour invasion and metastasis than E-cad expression.
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