ArticleThe American journal of pathology1994
Comparative genomic hybridization of human malignant gliomas reveals multiple amplification sites and nonrandom chromosomal gains and losses.
Article in The American journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 178 citations in OpenAlex.
- Diagnostic accuracy of 1p/19q codeletion tests in oligodendroglioma: A comprehensive meta-analysis based on a Cochrane systematic review.Neuropathology and applied neurobiology · 2022Pooled it
- Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma.The Cochrane database of systematic reviews · 2022Pooled it
- Implication of Contactins in Demyelinating Pathologies.Life (Basel, Switzerland) · 2021Review
- TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets.The Journal of clinical investigation · 2012Article
- Glioblastomas with oligodendroglial component-common origin of the different histological parts and genetic subclassification.Cellular oncology (Dordrecht, Netherlands) · 2011Article
- HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea.Neuro-oncology · 2010Article
- Array-based genomics in glioma research.Brain pathology (Zurich, Switzerland) · 2010Review
- Review
- Genomic alterations in low-grade, anaplastic astrocytomas and glioblastomas.Pathology oncology research : POR · 2007Article
- Microarray analysis of pediatric ependymoma identifies a cluster of 112 candidate genes including four transcripts at 22q12.1-q13.3.Neuro-oncology · 2005Article
- Advanced molecular cytogenetics in human and mouse.Expert review of molecular diagnostics · 2004Review
- Comparative genomic hybridization analysis of astrocytomas: prognostic and diagnostic implications.The Journal of molecular diagnostics : JMD · 2004Article
- The importance of genomic copy number changes in the prognosis of glioblastoma multiforme.Neurosurgical review · 2004Article
- Article
- Glioma-expressed antigen 2 (GLEA2): a novel protein that can elicit immune responses in glioblastoma patients and some controls.Clinical and experimental immunology · 2001Article
- Low frequency of chromosomal imbalances in anaplastic ependymomas as detected by comparative genomic hybridization.Brain pathology (Zurich, Switzerland) · 2001Article
- Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult cases.The American journal of pathology · 2001Article
- Progressive genetic aberrations detected by comparative genomic hybridization in squamous cell cervical cancer.British journal of cancer · 2000Article
- Comparative genomic hybridization and histological variation in primitive neuroectodermal tumours.British journal of cancer · 1999Article
- Amplification and expression of cyclin D genes (CCND1, CCND2 and CCND3) in human malignant gliomas.Brain pathology (Zurich, Switzerland) · 1999Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nine human malignant gliomas (2 astrocytomas grade III and 7 glioblastomas) were analyzed using comparative genomic hybridization (CGH). In addition to the amplification of the EGFR gene at 7p12 in 4 of 9 cases, six new amplification sites were mapped to 1q32, 4q12, 7q21.1, 7q21.2-3, 12p, and 22q12. Nonrandom chromosomal gains and losses were identified with overrepresentation of chromosome 7 and underrepresentation of chromosome 10 as the most frequent events (1 of 2 astrocytomas, 7 of 7 glioblastomas). Gain of a part or the whole chromosome 19 and losses of chromosome bands 9pter-23 and 22q13 were detected each in five cases. Loss of chromosome band 17p13 and gain of chromosome 20 were revealed each in three cases. The validity of the CGH data was confirmed using interphase cytogenetics with YAC clones, chromosome painting in tumor metaphase spreads, and DNA fingerprinting. A comparison of CGH data with the results of chromosome banding analyses indicates that metaphase spreads accessible in primary tumor cell cultures may not represent the clones predominant in the tumor tissue.
Indexed as
Identifiers
8203461PMC1887475W1666431833What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.