ArticleThe American journal of pathology1994
Bcl-2 expression in normal endometrium during the menstrual cycle.
Article in The American journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 151 citations in OpenAlex.
- Expression of Bcl-2 in node-negative breast cancer is associated with various prognostic factors, but does not predict response to one course of perioperative chemotherapy.British journal of cancer · 1996Trial
- The alteration of apoptosis-related genes in female pelvic supportive tissues with regard to menopausal status.Molecular biology reports · 2023Article
- Follicular Atresia, Cell Proliferation, and Anti-Mullerian Hormone in Two Neotropical Primates (Animals : an open access journal from MDPI · 2023Article
- Expression levels of BCL2 and MKI67 in endometrial polyps in postmenopausal women and their correlation with obesity.Molecular and clinical oncology · 2020Article
- Structural equation modelling analysis determining causal role among methyltransferases, methylation, and apoptosis during human pregnancy and abortion.Scientific reports · 2020Article
- Alteration of apoptosis-related genes in postmenopausal women with uterine prolapse.International urogynecology journal · 2014Article
- Association of genetic markers in the BCL-2 family of apoptosis-related genes with endometrial cancer risk in a Chinese population.PloS one · 2013Article
- Expression of apoptotic factors in vaginal tissues from women with urogenital prolapse.Neurourology and urodynamics · 2011Article
- Bcl-2 expression and p38MAPK activity in cells infected with influenza A virus: impact on virally induced apoptosis and viral replication.The Journal of biological chemistry · 2009Article
- Hormonal regulation of physiological cell turnover and apoptosis.Cell and tissue research · 2000Review
- Extensive molecular screening for hereditary non-polyposis colorectal cancer.British journal of cancer · 2000Article
- BCL2 regulates neural differentiation.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Bcl-2 immunoreactivity in prostate tumorigenesis in relation to prostatic intraepithelial neoplasia, grade, hormonal status, metastatic growth and survival.Urological research · 1996Article
- Bcl-2 expression and its association with cell kinetics in human gastric carcinomas and intestinal metaplasia.Journal of cancer research and clinical oncology · 1995Article
- Enhanced cellular proliferative activity and cell death in chronic thyroiditis and thyroid papillary carcinoma.Journal of cancer research and clinical oncology · 1995Article
- Bcl-2 may play a role in the progression of endometrial hyperplasia and early carcinogenesis, but not linked to further tumorigenesisJournal of microscopy and ultrastructureArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bcl-2 is a proto-oncogene initially described in the (14;18) translocation in follicular lymphoma. It has been shown to prolong cell survival by preventing apoptosis. Endometrium undergoes rapid proliferation and differentiation under hormone control and is thus an excellent model to study the hormone dependency of Bcl-2 expression. We studied Bcl-2 expression by an immunohistochemical method in 53 samples of normal endometrium randomly distributed throughout the menstrual cycle, as well as five samples of hyperplastic endometrium. Bcl-2 staining predominated in glandular cells and peaked at the end of the follicular phase. Bcl-2 expression disappeared at the onset of secretory activity. The stroma, surface lining epithelium and arterial vessels also displayed cyclic variations in Bcl-2 expression. These results strongly suggest hormone-dependent regulation of Bcl-2 expression, which could play an important role in tumorigenesis.
Indexed as
Identifiers
8203460PMC1887458W5304649What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.