ArticleProceedings of the National Academy of Sciences of the United States of America1994
Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed.
- Conserved and lineage-specific mechanisms drive chromatophore differentiation in reptiles.Nature communications · 2026Article
- Disruption of mc1r Disturbs Skin Pigmentation in Xenopus tropicalis.Pigment cell & melanoma research · 2025Article
- Plumage polymorphism in the black sparrowhawk (Accipiter melanoleucus) is strongly associated with the expression level of agouti signaling protein.The Journal of heredity · 2025Article
- A Dominant Mutation in GPigment cell & melanoma research · 2025Article
- Exosomal miR-222-3p derived from dermal papilla cells inhibits melanogenesis in melanocytes by targeting SOX10 in rabbits.Animal bioscience · 2025Article
- Agouti-Induced Anxiety-Like Behavior Is Mediated by Central Serotonergic Pathways in Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Mechanisms Underlying the Formation and Evolution of Vertebrate Color Patterns.Annual review of genetics · 2023Review
- Neural crest cells as a source of microevolutionary variation.Seminars in cell & developmental biology · 2023Review
- An enhancer ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- A 13.42-kb tandem duplication at the ASIP locus is strongly associated with the depigmentation phenotype of non-classic Swiss markings in goats.BMC genomics · 2022Article
- Article
- Dog colour patterns explained by modular promoters of ancient canid origin.Nature ecology & evolution · 2021Article
- Many ways to make darker flies: Intra- and interspecific variation inEcology and evolution · 2021Article
- The population genetics of crypsis in vertebrates: recent insights from mice, hares, and lizards.Heredity · 2020Review
- Transcriptome Reveals Multi Pigmentation Genes Affecting Dorsoventral Pattern in Avian Body.Frontiers in cell and developmental biology · 2020Article
- Selection signatures in goats reveal copy number variants underlying breed-defining coat color phenotypes.PLoS genetics · 2019Article
- The identification of genes involved in the evolution of color patterns in fish.Current opinion in genetics & development · 2019Review
- Periodic patterns in Rodentia: Development and evolution.Experimental dermatology · 2019Article
- Effect of isolation on coat colour polymorphism of Polynesian rats in Island Southeast Asia and the Pacific.PeerJ · 2019Article
- Comparative genomics and transcriptomics of Chrysolophus provide insights into the evolution of complex plumage coloration.GigaScience · 2018Article
1 more citing papers are in PubMed but not listed here.
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The agouti coat color gene encodes a paracrine signaling molecule that controls the production of yellow and black pigment by melanocytes within hair follicles. Some agouti alleles affect the dorsum and ventrum independently, which has provided the basis for speculation that agouti gene action in different regions of the body is controlled by distinct genetic loci that are closely linked. Using a combination of cDNA cloning and RNA expression studies, we find that alternative isoforms of agouti mRNA contain different noncoding first exons located 100 kb apart, whose patterns of expression indicate independent control by regulatory elements that are either ventral specific or hair cycle specific. These results demonstrate that the apparent genetic complexity of the agouti locus is explained by the existence of multiple regulatory elements exerting control over a single coding sequence and provide a conceptual basis for understanding differences in dorsal and ventral hair coloration in many mammalian species. The ventral-specific agouti isoform represents an example of a transcript whose expression is restricted to ventral skin and provide an approach to investigate the mechanisms by which dorsal-ventral differences in gene expression are established and maintained.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.