ArticleProceedings of the National Academy of Sciences of the United States of America1994
Structure and cell cycle-regulated transcription of the human cyclin A gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
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Who cites it
108 citing papers in PubMed, 269 citations in OpenAlex.
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- Bioactive molecule Icariin inhibited proliferation while enhanced apoptosis and autophagy of rat airway smooth muscle cells in vitro.Cytotechnology · 2019Article
- Clotam enhances anti-proliferative effect of vincristine in Ewing sarcoma cells.Apoptosis : an international journal on programmed cell death · 2019Article
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- Identification of novel cyclin gene fusion transcripts in endometrioid ovarian carcinomas.International journal of cancer · 2018Article
- Measuring cell cycle-dependent DNA damage responses and p53 regulation on a cell-by-cell basis from image analysis.Cell cycle (Georgetown, Tex.) · 2018Article
- Bisphosphonate inhibits the expression of cyclin A2 at the transcriptional level in normal human oral keratinocytes.International journal of molecular medicine · 2017Article
- New perspectives of cobalt tris(bipyridine) system: anti-cancer effect and its collateral sensitivity towards multidrug-resistant (MDR) cancers.Oncotarget · 2017Article
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- Single-cell protein-mRNA correlation analysis enabled by multiplexed dual-analyte co-detection.Scientific reports · 2017Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclin A is a cell cycle regulatory protein that functions in mitotic and S-phase control in mammalian somatic cells. Its deregulated expression may have a role in cellular transformation. We have cloned and sequenced the human cyclin A gene and cDNAs representing its mRNAs and have characterized its promoter. Using synchronized cultures of NIH 3T3 cells stably transfected with cyclin A promoter/luciferase constructs, we show that the promoter is repressed during the G1 phase of the cell cycle and is activated at S-phase entry. Cell cycle regulation of the cyclin A gene promoter is mediated by sequences extending from -79 to +100 relative to the predominant transcription start site. It does not require the presence of a functional retinoblastoma protein.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.