ArticleNucleic acids research1994
The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 86 citations in OpenAlex.
- Sequencing and Characterization of αs2-Casein Gene (Animals : an open access journal from MDPI · 2023Article
- Comparative parallel multi-omics analysis during the induction of pluripotent and trophectoderm states.Nature communications · 2022Article
- BET proteins are a key component of immunoglobulin gene expression.Epigenomics · 2017Article
- Octamer-binding transcription factors: genomics and functions.Frontiers in bioscience (Landmark edition) · 2013Review
- Anti-inflammatory cytokine interleukin-4 inhibits inducible nitric oxide synthase gene expression in the mouse macrophage cell line RAW264.7 through the repression of octamer-dependent transcription.Mediators of inflammation · 2013Article
- Oct-1 acts as a transcriptional repressor on the C-reactive protein promoter.Molecular immunology · 2012Article
- Oct-1 cooperates with the TATA binding initiation complex to control rapid transcription of human iNOS.Cellular and molecular life sciences : CMLS · 2012Article
- Replication stress induces 53BP1-containing OPT domains in G1 cells.The Journal of cell biology · 2011Article
- Involvement of the ubiquitous Oct-1 transcription factor in hormonal induction of beta-casein gene expression.The Biochemical journal · 2007Article
- Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.Molecular and cellular biology · 2005Article
- Identification of a POU factor involved in regulating the neuron-specific expression of the gene encoding diapause hormone and pheromone biosynthesis-activating neuropeptide in Bombyx mori.The Biochemical journal · 2004Article
- Oct-1 potentiates CREB-driven cyclin D1 promoter activation via a phospho-CREB- and CREB binding protein-independent mechanism.Molecular and cellular biology · 2002Article
- Role of tissue-specific transcription factor LFB3 in a cyclic AMP-responsive enhancer of the urokinase-type plasminogen activator gene in LLC-PK1 cells.Molecular and cellular biology · 1998Article
- Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site.Molecular and cellular biology · 1998Article
- Regional and temporal specialization in the nucleus: a transcriptionally-active nuclear domain rich in PTF, Oct1 and PIKA antigens associates with specific chromosomes early in the cell cycle.The EMBO journal · 1998Article
- Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription.The EMBO journal · 1997Article
- Efficient transcription of an immunoglobulin kappa promoter requires specific sequence elements overlapping with and downstream of the transcriptional start site.Nucleic acids research · 1997Article
- POU domain transcription factors in embryonic development.Molecular biology reports · 1997Review
- CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues.Nucleic acids research · 1997Article
- Transcriptional activation by Oct-3: evidence for a specific role of the POU-specific domain in mediating functional interaction with Oct-1.Nucleic acids research · 1996Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We had previously shown that the ubiquitous Oct1 and the lymphoid-specific Oct2 transcription factors stimulate transcription at the level of stable preinitiation complex formation. We have therefore investigated whether the octamer binding proteins might physically interact with TBP, the TATA box binding protein component of the TFIID factor. By using several different experimental systems we show that TBP efficiently associates with Oct1 and Oct2. The interaction is direct and does not depend on the presence of DNA or additional proteins. N- and C-terminal deletions of the different proteins were used to localize the domains involved in the interaction. We show that the POU homeodomain of Oct2 and the evolutionarily conserved C-terminal core domain of TBP are both required and sufficient for the interaction. The Oct1 POU domain, which is highly homologous to the Oct2 POU domain, likewise mediates interaction with TBP. The interaction can also be observed in vivo, as TBP can be co-precipitated with Oct2 from co-transfected Cos1 cells and TBP co-immunoprecipitates with the endogenous Oct1 from HeLa cells. Co-transfection of human TBP and Oct2 expression vectors into B cells resulted in a synergistic activation of an octamer motif containing promoter.
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