ArticleNucleic acids research1994
A sequence compilation and comparison of exons that are alternatively spliced in neurons.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 102 citations in OpenAlex.
- GC-AG Introns Features in Long Non-coding and Protein-Coding Genes Suggest Their Role in Gene Expression Regulation.Frontiers in genetics · 2020Article
- Article
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- Genome-wide analysis of alternative splicing in Volvox carteri.BMC genomics · 2014Article
- OLego: fast and sensitive mapping of spliced mRNA-Seq reads using small seeds.Nucleic acids research · 2013Article
- Refined characterization of the expression and stability of the SMN gene products.The American journal of pathology · 2007Article
- Differing patterns of selection in alternative and constitutive splice sites.Genome research · 2007Article
- The emergence of alternative 3' and 5' splice site exons from constitutive exons.PLoS computational biology · 2007Article
- A correlation with exon expression approach to identify cis-regulatory elements for tissue-specific alternative splicing.Nucleic acids research · 2007Article
- Comparative evolutionary genomics of the HADH2 gene encoding Abeta-binding alcohol dehydrogenase/17beta-hydroxysteroid dehydrogenase type 10 (ABAD/HSD10).BMC genomics · 2006Article
- Computational comparative analyses of alternative splicing regulation using full-length cDNA of various eukaryotes.RNA (New York, N.Y.) · 2004Article
- Impact of alternative initiation, splicing, and termination on the diversity of the mRNA transcripts encoded by the mouse transcriptome.Genome research · 2003Article
- Genome-wide detection of tissue-specific alternative splicing in the human transcriptome.Nucleic acids research · 2002Article
- Analysis of the role of Caenorhabditis elegans GC-AG introns in regulated splicing.Nucleic acids research · 2002Article
- Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.Molecular and cellular biology · 2002Article
- Human GC-AG alternative intron isoforms with weak donor sites show enhanced consensus at acceptor exon positions.Nucleic acids research · 2001Article
- Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing.Nucleic acids research · 2001Article
- Genomic sequence, splicing, and gene annotation.American journal of human genetics · 2000Review
- The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn).Molecular biology of the cell · 1999Article
- AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes.Molecular and cellular biology · 1999Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Alternative splicing is an important regulatory mechanism to create protein diversity. In order to elucidate possible regulatory elements common to neuron specific exons, we created and statistically analysed a database of exons that are alternatively spliced in neurons. The splice site comparison of alternatively and constitutively spliced exons reveals that some, but not all alternatively spliced exons have splice sites deviating from the consensus sequence, implying diverse patterns of regulation. The deviation from the consensus is most evident at the -3 position of the 3' splice site and the +4 and -3 position of the 5' splice site. The nucleotide composition of alternatively and constitutively spliced exons is different, with alternatively spliced exons being more AU rich. We performed overlapping k-tuple analysis to identify common motifs. We found that alternatively and constitutively spliced exons differ in the frequency of several trinucleotides that cannot be explained by the amino acid composition and may be important for splicing regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.