ArticleThe Journal of clinical investigation1994
Comparative analysis of the apo(a) gene, apo(a) glycoprotein, and plasma concentrations of Lp(a) in three ethnic groups. Evidence for no common "null" allele at the apo(a) locus.
Article in The Journal of clinical investigation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 127 citations in OpenAlex.
- A genome-wide association study on lipoprotein (a) levels and coronary artery disease severity in a Chinese population.Journal of lipid research · 2019Trial
- Lipoprotein(a) and Cardiovascular Disease in Chinese Population: A Beijing Heart Society Expert Scientific Statement.JACC. Asia · 2022Review
- A novel deletion mutation in the LPA gene in a middle-aged woman with ischaemic stroke.BMC medical genomics · 2021Article
- Serum Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is Independently Associated with Insulin Resistance, Triglycerides, Lipoprotein(a) Levels but not Low-Density Lipoprotein Cholesterol Levels in a General Population.Journal of atherosclerosis and thrombosis · 2021Article
- Nonsynonymous SNPs inJournal of lipid research · 2020Article
- Genetic Factors Explain a Major Fraction of the 50% Lower Lipoprotein(a) Concentrations in Finns.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Lipoprotein(a): A Lipoprotein Whose Time Has Come.Current treatment options in cardiovascular medicine · 2017Review
- Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology.Journal of lipid research · 2016Review
- Structure, function, and genetics of lipoprotein (a).Journal of lipid research · 2016Review
- Apolipoprotein(a) Kringle-IV Type 2 Copy Number Variation Is Associated with Venous Thromboembolism.PloS one · 2016Article
- Cholesterol Metabolism in CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015Review
- Sequence variation within the KIV-2 copy number polymorphism of the human LPA gene in African, Asian, and European populations.PloS one · 2015Article
- Association between high molecular weight apolipoprotein isoforms and lipoprotein levels in advanced chronic kidney disease and the effect of hemodialysis.Indian journal of nephrology · 2013Article
- Article
- Determination of lipoprotein(a) kringle repeat number from genomic DNA: copy number variation genotyping using qPCR.Journal of lipid research · 2009Article
- The apolipoprotein(a) gene: linkage disequilibria at three loci differs in African Americans and Caucasians.Atherosclerosis · 2008Article
- LPA and PLG sequence variation and kringle IV-2 copy number in two populations.Human heredity · 2008Article
- Lipoprotein(a): an elusive cardiovascular risk factor.Arteriosclerosis, thrombosis, and vascular biology · 2004Review
- Galactose-specific asialoglycoprotein receptor is involved in lipoprotein (a) catabolism.The Biochemical journal · 2003Article
- Lipoprotein (a) and stroke.Journal of clinical pathology · 2000Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Distributions of plasma lipoprotein(a) (Lp[a]) concentrations exhibit marked interracial differences. Apolipoprotein(a) (apo[a]), the unique constituent of Lp(a), is highly polymorphic in length due to allelic variations in the number of kringle 4(K-4)-encoding sequences. Plasma Lp(a) concentrations are inversely related to the number of K-4 repeats in the apo(a) alleles. To determine the contribution of this length variation to the interracial variation in plasma Lp(a) levels, we compared apo(a) allele size, glycoprotein size, and plasma Lp(a) concentrations in Caucasians, Chinese, and African Americans. Caucasians and African Americans had very different distributions of plasma Lp(a) concentrations yet there was no significant difference in the overall frequency distributions of their apo(a) alleles. Over the entire size spectrum of apo(a) alleles, the plasma Lp(a) levels were higher in African Americans than in Caucasians. Conversely, Caucasians and Chinese had similar plasma Lp(a) concentrations but significantly different apo(a) allele size distributions. Therefore, interracial differences in the plasma concentrations of Lp(a) are not due to differences in the frequency distributions of apo(a) alleles. We also examined the relationship between apo(a) allele size and the presence of detectable plasma apo(a) protein in plasma. Apo(a) alleles associated with no detectable plasma protein were not of uniformly large size, as had been expected, but were distributed over the entire size spectrum. From this analysis, we conclude that there is no common "null" allele at the apo(a) locus.
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