ArticleMammalian genome : official journal of the International Mammalian Genome Society1994
Chromosomal assignment of four genes encoding Na/H exchanger isoforms in human and rat.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 35 citations in OpenAlex.
- Carbon dioxide stunning of pigs induces the expression of fear-associated genes in the amygdala.Scientific reports · 2026Article
- SLC9 Gene Family: Function, Expression, and Regulation.Comprehensive Physiology · 2018Review
- Evidence for a Na+-H+ exchange across human colonic basolateral plasma membranes purified from organ donor colons.Digestive diseases and sciences · 2000Article
- Rat chromosome 1: regional localization of seven genes (Slc9a3, Srd5a1, Esr, Tcp1, Grik5, Tnnt3, Jak2) and anchoring of the genetic linkage map to the cytogenetic map.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Quantitative trait loci associated with promoting effects of sodium L-ascorbate on two-stage bladder carcinogenesis in rats.Japanese journal of cancer research : Gann · 1997Article
- A NHE3-related pseudogene is on human Chromosome 10; the functional gene maps to 5pl5.3.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- A genetic linkage map of the rat derived from recombinant inbred strains.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains.The Journal of clinical investigation · 1995Article
- Structure/function studies of mammalian Na-H exchangers--an update.The Journal of physiology · 1995Review
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plasma membrane Na/H exchanger plays an essential role in regulating intracellular pH and Na+ concentration and has been implicated in several pathophysiological conditions, including essential hypertension and congenital secretory diarrhea. Four isoforms of the Na/H exchanger encoded by separate genes have recently been identified by cDNA cloning. To map their locations in the human and rat genomes, rat isoform-specific cDNA probes were hybridized to Southern filters containing panels of somatic cell hybrids that segregate either human or rat chromosomes. The rat Nhe1 gene was assigned to Chromosome (Chr)5, extending the homology with human chromosome 1p that has previously been shown to contain the human NHE1 gene. The genes encoding the NHE-2 and NHE-4 isoforms were syntenic in the two species and assigned to rat Chr 9 and human Chr 2. A single Nhe3 gene was detected in rat and assigned to Chr 1. In contrast, although evidence to date has suggested a single human NHE3 gene on Chr 5, two NHE3 genes, NHE3A and NHE3B, were identified and assigned to Chrs 10 and 5, respectively. Interestingly, rat Chr 1 has recently been found to carry a gene controlling systolic blood pressure upon sodium loading in stroke-prone, spontaneously hypertensive rats. Thus, this and other evidence implicates rat Nhe3 as a possible candidate gene in this disease process.
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