ArticleInternational journal of experimental pathology1994
Pulmonary inflammation induced by repeated inhalations of beta(1,3)-D-glucan and endotoxin.
Article in International journal of experimental pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 132 citations in OpenAlex.
- Effects of ambient coarse, fine, and ultrafine particles and their biological constituents on systemic biomarkers: a controlled human exposure study.Environmental health perspectives · 2015Trial
- Endotoxin in concentrated coarse and fine ambient particles induces acute systemic inflammation in controlled human exposures.Occupational and environmental medicine · 2013Trial
- Effects after inhalation of (1-->3)-beta-D-glucan in healthy humans.Mediators of inflammation · 2001Trial
- Immunotoxicity of Inhalable Organic Dust Samples Based on In Vitro Analysis of Human Respiratory Epithelial Cells.International journal of molecular sciences · 2026Article
- Estimated exposure to endotoxin and circulating immunological markers among male farmers in the Biomarkers of Exposure and Effect in Agriculture study.Occupational and environmental medicine · 2025Article
- A Task-Specific Algorithm to Estimate Occupational (1→3)-β-D-glucan Exposure for Farmers in the Biomarkers of Exposure and Effect in Agriculture Study.Annals of work exposures and health · 2022Article
- Influence of Immune Status on the Airborne Colonization of Piglets with Methicillin-Resistant Staphylococcus aureus (MRSA) Clonal Complex (CC) 398.European journal of microbiology & immunology · 2020Article
- Comparison of the performance of ITS1 and ITS2 as barcodes in amplicon-based sequencing of bioaerosols.PeerJ · 2020Article
- Health and Environmental Risks of Residents Living Close to a Landfill: A Case Study of Thohoyandou Landfill, Limpopo Province, South Africa.International journal of environmental research and public health · 2019Article
- Recovery of Fungal Cells from Air Samples: a Tale of Loss and Gain.Applied and environmental microbiology · 2019Article
- C-Type Lectin Receptors in Asthma.Frontiers in immunology · 2018Review
- Respiratory Health in Waste Collection and Disposal Workers.International journal of environmental research and public health · 2016Article
- Fungal cell wall agents and bacterial lipopolysaccharide in organic dust as possible risk factors for pulmonary sarcoidosis.Journal of occupational medicine and toxicology (London, England) · 2016Article
- Otitis, rhinitis, and atopy in relation to domestic endotoxin and β-glucan exposure among children in Singapore.Environmental health and preventive medicine · 2010Article
- House dust (1-3)-beta-D-glucan and wheezing in infants.Allergy · 2007Article
- Meeting Abstracts. Recent Developments in 1,3-beta-Glucan Biology: Proceedings of the 5th Glucan Symposium Tokyo, December 8, 2006.Mediators of inflammation · 2007Article
- Airways inflammation among workers in poultry houses.International archives of occupational and environmental health · 2006Article
- (1-->3)-beta-D-glucan does not induce acute inflammation after nasal deposition.Mediators of inflammation · 2005Article
- Synergistic interaction in simultaneous exposure to Streptomyces californicus and Stachybotrys chartarum.Environmental health perspectives · 2004Article
- Slight respiratory irritation but not inflammation in mice exposed to (1-->3)-beta-D-glucan aerosols.Mediators of inflammation · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an animal model of hypersensitivity pneumonitis (HP) guinea-pigs were exposed for 5 weeks to an aerosol of bacterial endotoxin, beta(1,3)-D-glucan (curdlan) or a combination. Exposure to endotoxin or curdlan showed only small changes in inflammatory cells in airways or the lung wall, histologically or in terms of enzyme secretion from alveolar macrophages. When the two agents were given together, a histology resembling HP was seen with alveolar infiltrates and early granulomas. Inflammatory cells in airways were increased and enzyme production of macrophages was changed, suggesting an effect of curdlan on the inflammatory regulating capacity of airway macrophages. The results suggest that interference with macrophage function and inflammation are important components in the development of HP.
Indexed as
Identifiers
8199009PMC2002110W154465270What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.