ArticleProceedings of the National Academy of Sciences of the United States of America1994
Qualitative changes in the subunit composition of kappa B-binding complexes during murine B-cell differentiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 118 citations in OpenAlex.
- NF-κB/RelA signaling required for CD40-induced humoral immunity depends on specific NEMO lysine residues in mice.The EMBO journal · 2026Article
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- Chronic intermittent hypoxia worsens bleomycin-induced lung fibrosis in rats.Respiratory physiology & neurobiology · 2018Article
- Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling.Experimental cell research · 2015Article
- NF-κB and matrix-dependent regulation of osteopontin promoter activity in allylamine-activated vascular smooth muscle cells.Oxidative medicine and cellular longevity · 2012Article
- The NF-kappaB family of transcription factors and its regulation.Cold Spring Harbor perspectives in biology · 2009Review
- RNAi-mediated c-Rel silencing leads to apoptosis of B cell tumor cells and suppresses antigenic immune response in vivo.PloS one · 2009Article
- Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma.Molecular cancer · 2008Article
- A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles.Genome research · 2006Article
- RelA/p65 regulation of IkappaBbeta.Molecular and cellular biology · 2005Article
- Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkappaBalpha degradation in B cells.Molecular and cellular biology · 2004Article
- A mechanistic insight into a proteasome-independent constitutive inhibitor kappaBalpha (IkappaBalpha) degradation and nuclear factor kappaB (NF-kappaB) activation pathway in WEHI-231 B-cells.The Biochemical journal · 2004Article
- Review
- The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells.The Journal of experimental medicine · 2001Article
- Cell-specific association and shuttling of IkappaBalpha provides a mechanism for nuclear NF-kappaB in B lymphocytes.Molecular and cellular biology · 2001Article
- IkappaB kinase alpha is essential for mature B cell development and function.The Journal of experimental medicine · 2001Article
- Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement.The Journal of experimental medicine · 2000Article
- The molecular and cellular origins of Hodgkin's disease.The Journal of experimental medicine · 2000Review
- The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis.Genes & development · 1999Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report here that the major kappa B-binding complex in murine mature B cells is composed of a p50-Rel heterodimer, whereas the major inducible form in pre-B cells is a p50-p65 heterodimer. Treatment of a pre-B-cell line with lipopolysaccharide changes the subunit composition of kappa B-binding complexes from p50-p65 to p50-Rel. This change is preceded by the enhanced Rel expression and correlates with the expression of the gene for the immunoglobin kappa light chain. The heterodimeric p50-Rel complex binds to the intronic enhancer-kappa B site in the immunoglobulin kappa light chain gene at least 20-fold more stably than does the p50-p65 dimer. These data support a model in which augmentation of Rel expression during the differentiation of pre-B cells to mature B cells leads to an exchange of kappa B-binding subunits resulting in the transcriptional activation of the gene for the immunoglobulin kappa light chain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.