ArticleProceedings of the National Academy of Sciences of the United States of America1994
A G protein-coupled receptor with low density lipoprotein-binding motifs suggests a role for lipoproteins in G-linked signal transduction.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Genes linked to schistosome resistance identified in a genome-wide association study of African snail vectors.Nature communications · 2025Article
- Ancestral glycoprotein hormone-receptor pathway controls growth inFrontiers in endocrinology · 2023Article
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- Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins.The EMBO journal · 2012Review
- The repertoire of G protein-coupled receptors in the sea squirt Ciona intestinalis.BMC evolutionary biology · 2008Article
- A functional transmembrane complex: the luteinizing hormone receptor with bound ligand and G protein.Molecular and cellular endocrinology · 2007Review
- Gene structure and molecular phylogeny of the linker chains from the giant annelid hexagonal bilayer hemoglobins.Journal of molecular evolution · 2006Article
- Peptidomics of a single identified neuron reveals diversity of multiple neuropeptides with convergent actions on cellular excitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Expression pattern of the orphan receptor LGR4/GPR48 gene in the mouse.Histochemistry and cell biology · 2005Article
- Conservation of the heterodimeric glycoprotein hormone subunit family proteins and the LGR signaling system from nematodes to humans.Endocrine · 2005Article
- Classification of G-protein coupled receptors by alignment-independent extraction of principal chemical properties of primary amino acid sequences.Protein science : a publication of the Protein Society · 2002Article
- Neuropeptides and neuropeptide receptors in the Drosophila melanogaster genome.Genome research · 2001Article
- Molecular cloning, genomic organization, developmental regulation, and a knock-out mutant of a novel leu-rich repeats-containing G protein-coupled receptor (DLGR-2) from Drosophila melanogaster.Genome research · 2000Article
- Nucleic acid-binding properties of low-density lipoproteins: LDL as a natural gene vector.Journal of protein chemistry · 1999Article
- Stimulatory and inhibitory actions of lysophosphatidylcholine, depending on its fatty acid residue, on the phospholipase C/Ca2+ system in HL-60 leukaemia cells.The Biochemical journal · 1998Article
- The lymnaea cardioexcitatory peptide (LyCEP) receptor: a G-protein-coupled receptor for a novel member of the RFamide neuropeptide family.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Ligand-binding domains in vitellogenin receptors and other LDL-receptor family members share a common ancestral ordering of cysteine-rich repeats.Journal of molecular evolution · 1998Article
- Cloning, characterization, and expression of a G-protein-coupled receptor from Lymnaea stagnalis and identification of a leucokinin-like peptide, PSFHSWSamide, as its endogenous ligand.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have isolated and analyzed a cDNA from the central nervous system of the mollusc Lymnaea stagnalis encoding a putative receptor, which might be a natural hybrid between two different classes of receptor proteins. Preceded by a signal peptide, two types of repeated sequences are present in the N-terminal part of the protein. The first repeat displays a high sequence similarity to the extracellular binding domains of the low density lipoprotein receptor, which binds and internalizes cholesterol-containing apolipoproteins. The second repeat and the C-terminal part of the Lymnaea receptor are very similar to regions of a specific class of guanine nucleotide-binding protein-coupled receptors, the mammalian glycoprotein hormone receptors. The mRNA encoding the receptor is predominantly expressed in a small number of neurons within the central nervous system and to a lesser extent in the heart.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.