ArticleProceedings of the National Academy of Sciences of the United States of America1994
Adipocyte differentiation selectively represses the serum inducibility of c-jun and junB by reversible transcription-dependent mechanisms.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- A fine-mapping study of central obesity loci incorporating functional annotation and imputation.European journal of human genetics : EJHG · 2018Pooled it
- Identification ofAging · 2020Article
- Therapeutic Implications of PPARgamma in Human Osteosarcoma.PPAR research · 2010Article
- Increased tyrosine phosphorylation of the insulin receptor, the insulin receptor substrate-1 and a 73 kDa protein associated with insulin-induced mitogenesis in SV40-transformed 3T3T cells.Molecular and cellular biochemistry · 1999Article
- Induction of AP-1 activity associated with c-Jun and JunB is required for mitogenesis induced by insulin and vanadate in SV40-transformed 3T3T cells.Molecular and cellular biochemistry · 1997Article
- Differentiation modulates the balance of positive and negative Jun/AP-1 DNA binding activities to regulate cellular proliferative potential: different effects in nontransformed and transformed cells.The Journal of cell biology · 1996Article
- Unique and selective mitogenic effects of vanadate on SV40-transformed cells.Molecular and cellular biochemistryReview
- Chemically and photochemically initiated DNA cleavage by an insulin-mimetic bisperoxovanadium complex.Molecular and cellular biochemistryArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Nonterminally differentiated 3T3 T adipocytes are resistant to growth stimulation by 10% (vol/vol) fetal bovine serum even though they can be induced to proliferate with extremely high serum concentrations. We now report that in adipocytes 10% fetal bovine serum also fails to typically induce c-jun or junB. Rather, after 10% fetal bovine serum treatment, c-jun and junB expression is markedly repressed after a brief initial slight induction. Gel mobility shift studies confirm that AP-1 DNA binding activity is inhibited in adipocytes. Repression in c-jun and junB inducibility in adipocytes results from transcriptional mechanisms, can be reversed by treatment with protein synthesis inhibitors or higher serum concentrations, and does not affect c-fos or c-myc expression. These data suggest that adipocyte differentiation selectively and transcriptionally represses the inducibility of c-jun and junB so as to decrease the cell's ability to proliferate in response to 10% fetal bovine serum.
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Registered trials
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