ArticleMolecular and cellular biology1994
GATA elements are necessary for the activity and tissue specificity of the T-cell receptor beta-chain transcriptional enhancer.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 30 citations in OpenAlex.
- Multilayered specification of the T-cell lineage fate.Immunological reviews · 2010Review
- Article
- Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights.Journal of clinical immunology · 2003Review
- Structure and specificity of GATA proteins in Th2 development.Molecular and cellular biology · 2001Article
- Definition of a T-cell receptor beta gene core enhancer of V(D)J recombination by transgenic mapping.Molecular and cellular biology · 2000Article
- A conserved tissue-specific structure at a human T-cell receptor beta-chain core promoter.Molecular and cellular biology · 1997Article
- Direct and indirect mechanisms of repression participate in suppression of T-cell-specific gene expression in T x L-cell hybrids.Gene expression · 1996Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Three high-affinity binding sites for the GATA family of transcriptional regulators have been identified within the T-cell receptor beta-chain (TCR beta) transcriptional enhancer, and their functional significance has been determined in an effort to understand the T-cell specificity of the enhancer more fully. One site, TE4, is important for activity of the enhancer in T cells. Neither site TE1 nor site TE2 can functionally replace a mutated TE4 site in T cells; however, the same protein, probably GATA-3, binds all three sites, as judged by electrophoretic mobility shift, oligonucleotide competition, and proteolytic clipping assays. These data suggest that additional proteins are critical for the ability of GATA-3 to activate the TCR beta enhancer. In fibroblasts, the GATA sequence at site TE1 appears to bind a negative regulator. Since this is not true in B cells, B cells and fibroblasts appear to have different mechanisms for negative regulation of the TCR beta enhancer.
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Registered trials
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