ArticleMolecular and cellular biology1994
The human cut homeodomain protein represses transcription from the c-myc promoter.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 93 citations in OpenAlex.
- Transcription of the human EAP1 gene is regulated by upstream components of a puberty-controlling Tumor Suppressor Gene network.Molecular and cellular endocrinology · 2012Article
- Transcriptional regulation of the human KiSS1 gene.Molecular and cellular endocrinology · 2011Article
- Article
- CCAAT displacement protein regulates nuclear factor-kappa beta-mediated chemokine transcription in melanoma cells.Melanoma research · 2007Article
- Differentiation-induced cleavage of Cutl1/CDP generates a novel dominant-negative isoform that regulates mammary gene expression.Molecular and cellular biology · 2006Article
- Hepatomegaly in transgenic mice expressing the homeobox gene Cux-1.Molecular carcinogenesis · 2005Article
- Analysis of the interaction of the adenovirus L1 52/55-kilodalton and IVa2 proteins with the packaging sequence in vivo and in vitro.Journal of virology · 2005Article
- Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The homeodomain protein CDP regulates mammary-specific gene transcription and tumorigenesis.Molecular and cellular biology · 2004Article
- CDP/Cux stimulates transcription from the DNA polymerase alpha gene promoter.Molecular and cellular biology · 2003Article
- A novel colonic repressor element regulates intestinal gene expression by interacting with Cux/CDP.Molecular and cellular biology · 2002Article
- Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia.Developmental biology · 2002Article
- Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility.Molecular and cellular biology · 2002Article
- CDP binding to multiple sites in the mouse mammary tumor virus long terminal repeat suppresses basal and glucocorticoid-induced transcription.Journal of virology · 2002Article
- S phase-specific proteolytic cleavage is required to activate stable DNA binding by the CDP/Cut homeodomain protein.Molecular and cellular biology · 2001Article
- C/EBP epsilon mediates myeloid differentiation and is regulated by the CCAAT displacement protein (CDP/cut).Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- CDP is a repressor of mouse mammary tumor virus expression in the mammary gland.Journal of virology · 2000Article
- Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies of the c-myc promoter have shown that efficient transcription initiation at the P2 start site as well as the block to elongation of transcription require the presence of the ME1a1 protein binding site upstream of the P2 TATA box. Following fractionation by size exclusion chromatography, three protein-ME1a1 DNA complexes, a, b, and c, were detected by electrophoretic mobility shift assay. A cDNA encoding a protein present in complex c was isolated by screening of an expression library with an ME1a1 DNA probe. This cDNA was found to encode the human homolog of the Drosophila Cut homeodomain protein. The bacterially expressed human Cut (hu-Cut) protein bound to the ME1a1 site, and antibodies against hu-Cut inhibited the ME1a1 binding activity c in nuclear extracts. In cotransfection experiments, the hu-Cut protein repressed transcription from the c-myc promoter, and this repression was shown to be dependent on the presence of the ME1a1 site. Using a reporter construct with a heterologous promoter, we found that c-myc exon 1 sequences were also necessary, in addition to the ME1a1 site, for repression by Cut. Taken together, these results suggest that the human homolog of the Drosophila Cut homeodomain protein is involved in regulation of the c-myc gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.