ArticleThe Journal of cell biology1994
Transformation by myc prevents fusion but not biochemical differentiation of C2C12 myoblasts: mechanisms of phenotypic correction in mixed culture with normal cells.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- CRISPR/Cas9/AAV9-mediated in vivo editing identifies MYC regulation of 3D genome in skeletal muscle stem cell.Stem cell reports · 2021Article
- c-Myc inhibits myoblast differentiation and promotes myoblast proliferation and muscle fibre hypertrophy by regulating the expression of its target genes, miRNAs and lincRNAs.Cell death and differentiation · 2019Article
- A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.Nature genetics · 2014Article
- Mitochondria as a potential regulator of myogenesis.TheScientificWorldJournal · 2013Review
- Wnt7a-Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle.Nature cell biology · 2011Article
- Canonical Wnt signaling is involved in switching from cell proliferation to myogenic differentiation of mouse myoblast cells.Journal of molecular signaling · 2011Article
- Heparin mimicking polymer promotes myogenic differentiation of muscle progenitor cells.Biomacromolecules · 2010Article
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- p53 regulates myogenesis by triggering the differentiation activity of pRb.The Journal of cell biology · 2000Article
- The role of wild-type p53 in the differentiation of primary hemopoietic and muscle cells.Oncogene · 1999Article
- The v-myc oncogene.Oncogene · 1999Review
- A role for the putative tumor suppressor Bin1 in muscle cell differentiation.Molecular and cellular biology · 1998Article
- Carcinoembryonic antigen, a human tumor marker, cooperates with Myc and Bcl-2 in cellular transformation.The Journal of cell biology · 1997Article
- Interference with p53 protein inhibits hematopoietic and muscle differentiation.The Journal of cell biology · 1996Article
- Normal rat intestinal cells IEC-18: characterization and transfection with immortalizing oncogenes.Cytotechnology · 1996Article
- The inhibition of cultured myoblast differentiation by the simian virus 40 large T antigen occurs after myogenin expression and Rb up-regulation and is not exerted by transformation-competent cytoplasmic mutants.Journal of virology · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study the effects of myc oncogene on muscle differentiation, we infected the murine skeletal muscle cell line C2C12 with retroviral vectors encoding various forms of avian c- or v-myc oncogene. myc expression induced cell transformation but, unlike many other oncogenes, prevented neither biochemical differentiation, nor commitment (irreversible withdrawal from the cell cycle). Yet, myotube formation by fusion of differentiated cells was strongly inhibited. Comparison of uninfected C2C12 myotubes with differentiated myc-expressing C2C12 did not reveal consistent differences in the expression of several muscle regulatory or structural genes. The present results lead us to conclude that transformation by myc is compatible with differentiation in C2C12 cells. myc expression induced cell death under growth restricting conditions. Differentiated cells escaped cell death despite continuing expression of myc, suggesting that the muscle differentiation programme interferes with the mechanism of myc-induced cell death. Cocultivation of v-myc-transformed C2C12 cells with normal fibroblasts or myoblasts restored fusion competence and revealed two distinguishable mechanisms that lead to correction of the fusion defect.
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