ArticleThe EMBO journal1994
Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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Who cites it
98 citing papers in PubMed, 359 citations in OpenAlex.
- Recombinant biosensors for multiplex and super-resolution imaging of phosphoinositides.The Journal of cell biology · 2024Article
- The Phosphorylation of Kv1.3: A Modulatory Mechanism for a Multifunctional Ion Channel.Cancers · 2023Review
- Protein kinases: master regulators of neuritogenesis and therapeutic targets for axon regeneration.Cellular and molecular life sciences : CMLS · 2020Review
- The therapeutic potential of insulin-like growth factor-1 in central nervous system disorders.Neuroscience and biobehavioral reviews · 2016Review
- The H1047R point mutation in p110 alpha changes the morphology of human colon HCT116 cancer cells.Cell death discovery · 2015Article
- PI3K signalling: the path to discovery and understanding.Nature reviews. Molecular cell biology · 2012Article
- Regulation of gastric acid secretion by the serum and glucocorticoid inducible kinase isoform SGK3.Journal of gastroenterology · 2011Article
- Phosphoinositide 3-kinase-dependent regulation of Na+/H+ exchanger in dendritic cells.Pflugers Archiv : European journal of physiology · 2010Article
- Regulation of basal gastric acid secretion by the glycogen synthase kinase GSK3.Journal of gastroenterology · 2010Article
- Regulation of gastric acid secretion by PKB/Akt2.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2010Article
- Cadherin-mediated intercellular adhesion and signaling cascades involving small GTPases.Cold Spring Harbor perspectives in biology · 2009Review
- Chronic blockade of phosphatidylinositol 3-kinase in the nucleus tractus solitarii is prohypertensive in the spontaneously hypertensive rat.Hypertension (Dallas, Tex. : 1979) · 2009Article
- Role of the serum and glucocorticoid inducible kinase SGK1 in glucocorticoid stimulation of gastric acid secretion.Pflugers Archiv : European journal of physiology · 2007Article
- Pathogenesis of leptospirosis: interaction of Leptospira interrogans with in vitro cultured mammalian cells.Medical microbiology and immunology · 2007Article
- Heterotypic RPE-choroidal endothelial cell contact increases choroidal endothelial cell transmigration via PI 3-kinase and Rac1.Experimental eye research · 2007Article
- PI3-kinase-dependent electrogenic intestinal transport of glucose and amino acids.Pflugers Archiv : European journal of physiology · 2007Article
- Renal Ca2+ handling in sgk1 knockout mice.Pflugers Archiv : European journal of physiology · 2006Article
- Decreased intestinal glucose transport in the sgk3-knockout mouse.Pflugers Archiv : European journal of physiology · 2005Article
- Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement.Molecular and cellular biology · 2005Article
- Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT.The Journal of experimental medicine · 2003Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin, IGF-1 or EGF induce membrane ruffling through their respective tyrosine kinase receptors. To elucidate the molecular link between receptor activation and membrane ruffling, we microinjected phosphorylated peptides containing YMXM motifs or a mutant 85 kDa subunit of phosphoinositide (PI) 3-kinase (delta p85) which lacks a binding site for the catalytic 110 kDa subunit of PI 3-kinase into the cytoplasm of human epidermoid carcinoma KB cells. Both inhibited the association of insulin receptor substrate-1 (IRS-1) with PI 3-kinase in a cell-free system and also inhibited insulin- or IGF-1-induced, but not EGF-induced, membrane ruffling in KB cells. Microinjection of nonphosphorylated analogues, phosphorylated peptides containing the EYYE motif or wild-type 85 kDa subunit (Wp85), all of which did not inhibit the association of IRS-1 with PI 3-kinase in a cell-free system, did not inhibit membrane ruffling in KB cells. In addition, wortmannin, an inhibitor of PI 3-kinase activity, inhibited insulin- or IGF-1-induced membrane ruffling. These results suggest that the association of IRS-1 with PI 3-kinase followed by the activation of PI 3-kinase are required for insulin- or IGF-1-induced, but not for EGF-induced, membrane ruffling.
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