ArticleNucleic acids research1994
Different binding specificities and transactivation of variant CRE's by CREB complexes.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 142 citations in OpenAlex.
- A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response.Frontiers in molecular neuroscience · 2023Review
- Review
- The effect of Jun dimerization on neurite outgrowth and motif binding.Molecular and cellular neurosciences · 2018Article
- Integrated microfluidic approach for quantitative high-throughput measurements of transcription factor binding affinities.Nucleic acids research · 2016Article
- Single-Molecule Imaging Reveals Dynamics of CREB Transcription Factor Bound to Its Target Sequence.Scientific reports · 2015Article
- The transcription factor Mesp1 interacts with cAMP-responsive element binding protein 1 (Creb1) and coactivates Ets variant 2 (Etv2) gene expression.The Journal of biological chemistry · 2015Article
- Inversion of Sonic hedgehog action on its canonical pathway by electrical activity.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- cJun and CREB2 in the postsynaptic neuron contribute to persistent long-term facilitation at a behaviorally relevant synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Clustered regulatory elements at nucleosome-depleted regions punctuate a constant nucleosomal landscape in Schizosaccharomyces pombe.BMC genomics · 2013Article
- CG methylated microarrays identify a novel methylated sequence bound by the CEBPB|ATF4 heterodimer that is active in vivo.Genome research · 2013Article
- Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay.Nature biotechnology · 2012Article
- Article
- Melatonin synthesis in retina: cAMP-dependent transcriptional regulation of chicken arylalkylamine N-acetyltransferase by a CRE-like sequence and a TTATT repeat motif in the proximal promoter.Journal of neurochemistry · 2011Article
- ZEB1 limits adenoviral infectability by transcriptionally repressing the coxsackie virus and adenovirus receptor.Molecular cancer · 2011Article
- Article
- cJun modulates Ggamma-globin gene expression via an upstream cAMP response element.Blood cells, molecules & diseases · 2010Article
- Multiple transcription factor codes activate epidermal wound-response genes in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2.The Journal of biological chemistry · 2008Article
- A whole genome association study of neuroticism using DNA pooling.Molecular psychiatry · 2008Article
- Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The DNA binding specificities of CREB1 and CREB2 homodimers and the CREB2/cJun heterodimer were analyzed with a CASTing technique. All but one of the selected sequences varied from the consensus CRE (TGACGTCA) by three nucleotides or less. The profile of variations selected and the binding affinity for these sequences were unique for each CREB complex. The affinities were not effected by the palindromic nature of the sequences, but were strongly effected by flanking sequences. The strength of DNA binding in vitro correlated with the degree of transactivation observed in JEG-3 cells transfected with reporter plasmids harboring CRE variants, when hybrid CREB proteins fused to the VP16 activation domain were expressed. When native CREB proteins were expressed, the correlation was attenuated by the nature of the variant sequence. A CRE variant (TGACATCA) found in several natural promoters, exhibited the lowest basal transcription rate of the variants and a lower level of induction than expected when compared with the in vitro binding data. These results indicate that transactivation of DNA sequence elements is strongly effected by the strength of transcription factor binding, and that individual sequences can attenuate the level of induction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.