ArticleMolecular & general genetics : MGG1994
Polyubiquitin gene expression contributes to oxidative stress resistance in respiratory yeast (Saccharomyces cerevisiae).
Article in Molecular & general genetics : MGG, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 82 citations in OpenAlex.
- Stress granule formation is regulated by signaling machinery involving Sch9/Ypk1, sphingolipids, and Ubi4.Theranostics · 2025Article
- Induction of point and structural mutations in engineered yeast Saccharomyces cerevisiae improve carotenoid production.World journal of microbiology & biotechnology · 2024Article
- Article
- Ubiquitin-Conjugating Enzymes Ubc1 and Ubc4 Mediate the Turnover of Hap4, a Master Regulator of Mitochondrial Biogenesis inMicroorganisms · 2022Article
- Multiple F-Box Proteins Collectively Regulate Cell Development and Pathogenesis in the Human PathogenJournal of fungi (Basel, Switzerland) · 2022Article
- Yeast polyubiquitin unit regulates synaptonemal complex formation and recombination during meiosis.Journal of microbiology (Seoul, Korea) · 2022Article
- Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease.Scientific reports · 2021Article
- Elevated post-ischemic ubiquitination results from suppression of deubiquitinase activity and not proteasome inhibition.Cellular and molecular life sciences : CMLS · 2021Article
- Effect of UV Laser Radiation on "Positive Regulation of Telomere Maintenance" inJournal of lasers in medical sciences · 2021Article
- Identification of ubiquitin Ser57 kinases regulating the oxidative stress response in yeast.eLife · 2020Article
- The Ubiquitin Moiety of Ubi1 Is Required for Productive Expression of Ribosomal Protein eL40 inCells · 2019Article
- The polyubiquitin geneGenes · 2019Article
- Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival.Nature communications · 2017Article
- Transcriptome Profiles of Populus euphratica upon Heat Shock stress.Current genomics · 2014Article
- Expression of stress-related genes in zebrawood (Astronium fraxinifolium, Anacardiaceae) seedlings following germination in microgravity.Genetics and molecular biology · 2014Article
- Overexpression of ubiquitin and amino acid permease genes in association with antimony resistance in Leishmania tropica field isolates.The Korean journal of parasitology · 2013Article
- The genome-wide early temporal response of Saccharomyces cerevisiae to oxidative stress induced by cumene hydroperoxide.PloS one · 2013Article
- Protein expression of ubiquitin in interscapular brown adipose tissue during acclimation of rats to cold: the impact of (∙)NO.Molecular and cellular biochemistry · 2012Article
- Roles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degeneration.Molecular aspects of medicine · 2012Review
- Posttranslational modifications of proteins in the pathobiology of medically relevant fungi.Eukaryotic cell · 2012Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
UBI4, the polyubiquitin gene of Saccharomyces cerevisiae, is expressed at a low level in vegetative cells, yet induced strongly in response to starvation, cadmium, DNA-damaging agents and heat shock. UBI4 is also expressed at a higher basal level in cells growing by respiration as compared to glucose-repressed cells growing by fermentation. This higher UBI4 expression of respiratory cultures probably helps to counteract the greater oxidative stress of respiratory growth. The effects of inactivating UBI4 on high temperature viability are more marked with respiratory cultures. Also loss of UBI4 leads to a considerably increased rate of killing of respiring cells by hydrogen peroxide, whereas the same gene inactivation has relatively little effect on the peroxide sensitivity of cells in which mitochondrial functions are repressed. This is the first study to reveal that ubiquitin levels in cells can influence their ability to withstand oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.