Evidence map›Paper›PMID 8189542›Full record

ArticleJournal of virology1994

A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia.

M E Hoatlin, F E Ferro, S L Kozak, D Kabat

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

M E HoatlinDepartment of Biochemistry and Molecular Biology, School of Medicine, Oregon Health Sciences University, Portland 97201-3098.
F E Ferro
S L Kozak
D Kabat
Oregon Health & Science University · US

Funding

LEUKEMOGENIC RETROVIRAL GLYCOPROTEIN: GP55-GP70SR01CA025810 · NCI · OREGON HEALTH AND SCIENCE UNIVERSITY · PI KABAT, DAVID · 1985 to 2001
$414k
ERYTHROPOIETIN RECEPTORS IN LEUKEMIAR01CA054149 · NCI · OREGON HEALTH AND SCIENCE UNIVERSITY · PI KABAT, DAVID · 1991 to 1999
–
NCI NIH HHS CA25810NCI NIH HHS CA54149
6 · The paper itself

Abstract

The Pvu delta mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, Pvu delta causes erythroblastosis and the development of erythroleukemia. We isolated two leukemic cell lines that contain Pvu delta; both synthesize hemoglobin in response to dimethyl sulfoxide. The Pvu delta env gene contains a 204-base deletion in the ecotropic-specific region, suggesting that this domain of the glycoprotein is not essential for viral pathogenesis.

Indexed as

Amino Acid SequenceAnimalsBase SequenceDNA PrimersDNA, ViralFriend murine leukemia virusGene Products, envLeukemia, Erythroblastic, AcuteMiceMolecular Sequence DataMutationReceptors, ErythropoietinRetroviridae InfectionsSequence Homology, Amino AcidTumor Cells, CulturedTumor Virus InfectionsDNA PrimersDNA, ViralGene Products, envReceptors, Erythropoietin

Identifiers

PMID8189542
PMCPMC236916
OpenAlexW1507616313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.