ArticleThe Journal of cell biology1994
Association of the transmembrane TGF-alpha precursor with a protein kinase complex.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 82 citations in OpenAlex.
- Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth.Journal of cell science · 2010Article
- Activator protein 2alpha mediates parathyroid TGF-alpha self-induction in secondary hyperparathyroidism.Journal of the American Society of Nephrology : JASN · 2008Article
- The cytoplasmic domain of proEGF negatively regulates motility and elastinolytic activity in thyroid carcinoma cells.Neoplasia (New York, N.Y.) · 2008Article
- EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands.Cancer science · 2008Review
- Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter.Molecular and cellular biology · 2004Article
- Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55.The EMBO journal · 2000Article
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- Stimulation of cleavage of membrane proteins by calmodulin inhibitors.The Biochemical journal · 2000Article
- The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation.The Journal of cell biology · 2000Article
- Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-alpha homolog Spitz.Genes & development · 2000Article
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- Immunolocalization of transforming growth factor-alpha and epidermal growth factor receptor in the rat gastroduodenal area.Digestive diseases and sciences · 1999Article
- The expression of transforming growth factor alpha receptor protein and its activation in chicken ovarian granulosa cells of maturing follicles.The Histochemical journal · 1998Article
- The carboxyl-terminal valine residues of proTGF alpha are required for its efficient maturation and intracellular routing.Molecular biology of the cell · 1997Article
- Extracellular matrix regulates whey acidic protein gene expression by suppression of TGF-alpha in mouse mammary epithelial cells: studies in culture and in transgenic mice.The Journal of cell biology · 1995Article
- The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor.The Journal of cell biology · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A variety of growth factors including transforming growth factor-alpha (TGF-alpha) are synthesized as transmembrane precursors. The short cytoplasmic domain of the transmembrane TGF-alpha precursor lacks any apparent motif associated with signal transduction. However, the sequence conservation of this cytoplasmic domain and its abundance of cysteine residues, reminiscent of the cytoplasmic domains of CD4 and CD8, suggest a biological function. In this study, we showed that transmembrane TGF-alpha was rapidly internalized after interaction with a specific antibody and that this internalization was greatly decreased when the COOH-terminal 31 amino acids were removed. Chemical cross-linking experiments revealed two associated proteins of 86 and 106 kD which coimmunoprecipitated with the TGF-alpha precursor. The association of p86 was dependent on the presence of the COOH-terminal cytoplasmic 31 amino acids of the TGF-alpha precursor, whereas p106 still remained associated when this segment was deleted. In addition, p106 was tyrosine-phosphorylated and exposed on the cell surface. The protein complex associated with transmembrane TGF-alpha displayed kinase activities towards tyrosine, serine, and threonine residues. These activities were not associated with transmembrane TGF-alpha when the COOH-terminal segment was truncated. The association of a protein kinase complex with transmembrane TGF-alpha may provide the basic elements for a "reverse" mode of signaling through the cytoplasmic domain of this growth factor, which may lead to two-directional communication during ligand-receptor interaction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.