ArticleInfection and immunity1994
Immunopathological features of rat Staphylococcus aureus arthritis.
Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 55 citations in OpenAlex.
- Surface-Shaving ofMicroorganisms · 2024Article
- Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapies.Frontiers in microbiology · 2024Review
- Staphylococcus aureus Infection Induces the Production of the Neutrophil Chemoattractants CXCL1, CXCL2, CXCL3, CXCL5, CCL3, and CCL7 by Murine Osteoblasts.Infection and immunity · 2023Article
- Apoptosis-associated uncoupling of bone formation and resorption in osteomyelitis.Frontiers in cellular and infection microbiology · 2013Review
- Anti-staphylococcal activities of lysostaphin and LytM catalytic domain.BMC microbiology · 2012Article
- The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis.Arthritis research & therapy · 2009Review
- Osteoblast responses to bacterial pathogens: a previously unappreciated role for bone-forming cells in host defense and disease progression.Immunologic research · 2004Review
- Bacterium-induced CXCL10 secretion by osteoblasts can be mediated in part through toll-like receptor 4.Infection and immunity · 2002Article
- Complement depletion aggravates Staphylococcus aureus septicaemia and septic arthritis.Clinical and experimental immunology · 1999Article
- Role of neutrophils in experimental septicemia and septic arthritis induced by Staphylococcus aureus.Infection and immunity · 1997Article
- Role of intercellular adhesion molecule 1 in pathogenesis of staphylococcal arthritis and in host defense against staphylococcal bacteremia.Infection and immunity · 1996Article
- Vitamin A deficiency predisposes to Staphylococcus aureus infection.Infection and immunity · 1996Article
- Role of superantigens in experimental arthritis.Springer seminars in immunopathology · 1996Review
- Overexpression of the T-cell receptor V beta 3 in transgenic mice increases mortality during infection by enterotoxin A-producing Staphylococcus aureus.Infection and immunity · 1995Article
- Preferential induction of septic arthritis and mortality by superantigen-producing staphylococci.Infection and immunity · 1995Article
- Protective role of sialophorin (CD43)-expressing cells in experimental Staphylococcus aureus infection.Infection and immunity · 1994Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus is the most common bacterial species found in nongonococcal bacterial arthritis in humans. We present the first description, to our knowledge, of an outbreak of spontaneous staphylococcal arthritis in a rat colony. In a group of 10 rats, 9 displayed arthritis. Clinically, the most obvious findings were arthritis of one or both hindpaws and malaise. Bacteriophage typing showed the common phage type 85 in isolates recovered from the joints, blood, and bedding of rats and from the nose and cheeks of one person from the staff of the animal facility. The S. aureus strain proved to produce staphylococcal enterotoxin A and exhibited strong binding to collagen types I and II and bone sialoprotein, which are potentially important virulence factors. When the recovered S. aureus strain was injected intravenously into healthy rats, severe septic arthritis was induced in almost all of the animals. The arthritic lesions were characterized by infiltration of phagocytic cells and T lymphocytes into the synovium. Many of the synovial cells strongly expressed major histocompatibility complex class II molecules. Increased levels of interleukin 6 in serum as well as a prominent polyclonal B-cell activation were noted throughout the disease course. Pretreatment of S. aureus-injected rats in vivo with an antibody to the alpha beta T-cell receptor significantly decreased the severity of the arthritis. Our results indicate that alpha beta + T lymphocytes contribute to an erosive and persistent course of S. aureus arthritis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.