ArticleVirchows Archiv : an international journal of pathology1994
Morphometric analysis of intestinal mucosa. VI--Principles in enumerating intra-epithelial lymphocytes.
Article in Virchows Archiv : an international journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Microscopic enteritis: Bucharest consensus.World journal of gastroenterology · 2015Guideline
- From 2-dimensional to 3-dimensional: Overcoming dilemmas in intestinal mucosal interpretation.World journal of gastroenterology · 2019Review
- Diagnosing celiac disease: A critical overview.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Review
- Article
- Evolutionary Developments in Interpreting the Gluten-Induced Mucosal Celiac Lesion: An Archimedian Heuristic.Nutrients · 2017Review
- Lymphocytic duodenitis or microscopic enteritis and gluten-related conditions: what needs to be explored?Annals of gastroenterology · 2017Review
- Coeliac disease, mucosal change and IEL: doing what counts the best.Gastroenterology and hepatology from bed to bench · 2016Article
- What is the best histopathological classification for celiac disease? Does it matter?Gastroenterology and hepatology from bed to bench · 2015Article
- Mucosal T cells in gut homeostasis and inflammation.Expert review of clinical immunology · 2010Article
- Coeliac disease: an update for pathologists.Journal of clinical pathology · 2006Review
- Review
- Quantitation of intraepithelial lymphocytes in human duodenum: what is normal?Journal of clinical pathology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mucosal response by intra-epithelial lymphocytes (IEL) to antigenic challenge is a useful monitor of local immune activity. Conventional counts of IEL (determined as profile ratios of IEL to enterocyte nuclei) are inaccurate, and over-estimate values by a factor of two, both for disease-control mucosae and untreated 'flat' gluten-sensitized mucosae. Two further proofs are advanced in this paper which expose the inaccuracy of conventional profile-density IEL counts. New ranges (log-transformed data) indicate a disease-control mean of 11 IEL per 100 enterocytes (95% confidence limits 5-27) and 29 IEL per 100 enterocytes (95% confidence limits 14-61) for untreated flat gluten-sensitive mucosae. For simplicity, if conventional IEL "counts" are halved, correct values (based on precise morphometric analyses) are easily obtained for comparative and other purposes.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.