ArticleMolecular biology of the cell1994
Phylogeny and expression of axonemal and cytoplasmic dynein genes in sea urchins.
Article in Molecular biology of the cell, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 169 citations in OpenAlex.
- Ahi1 promotes Arl13b ciliary recruitment, regulates Arl13b stability and is required for normal cell migration.Journal of cell science · 2019Article
- Emerging mechanisms of dynein transport in the cytoplasm versus the cilium.Biochemical Society transactions · 2018Review
- Kinesin-2 motors adapt their stepping behavior for processive transport on axonemes and microtubules.EMBO reports · 2017Article
- Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery.The FEBS journal · 2017Review
- Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements.Nature structural & molecular biology · 2017Article
- Intraflagellar Transport and Ciliary Dynamics.Cold Spring Harbor perspectives in biology · 2017Review
- The trafficking of bacterial type rhodopsins into the Chlamydomonas eyespot and flagella is IFT mediated.Scientific reports · 2016Article
- Cellular Mechanisms of Ciliary Length Control.Cells · 2016Review
- Dynein and intraflagellar transport.Experimental cell research · 2015Review
- Variation in DNAH1 may contribute to primary ciliary dyskinesia.BMC medical genetics · 2015Article
- Subunit composition of the human cytoplasmic dynein-2 complex.Journal of cell science · 2014Article
- Article
- Exome sequencing identifies DYNC2H1 mutations as a common cause of asphyxiating thoracic dystrophy (Jeune syndrome) without major polydactyly, renal or retinal involvement.Journal of medical genetics · 2013Article
- Unconventional functions of microtubule motors.Archives of biochemistry and biophysics · 2012Review
- A role for Tctex-1 (DYNLT1) in controlling primary cilium length.European journal of cell biology · 2011Article
- Article
- Patterns of kinesin evolution reveal a complex ancestral eukaryote with a multifunctional cytoskeleton.BMC evolutionary biology · 2010Article
- Dynein-2 affects the regulation of ciliary length but is not required for ciliogenesis in Tetrahymena thermophila.Molecular biology of the cell · 2009Article
- A protein methylation pathway in Chlamydomonas flagella is active during flagellar resorption.Molecular biology of the cell · 2008Article
- Intraflagellar transport motors in cilia: moving along the cell's antenna.The Journal of cell biology · 2008Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Transcripts approximately 14.5 kilobases in length from 14 different genes that encode for dynein heavy chains have been identified in poly(A)+ RNA from sea urchin embryos. Analysis of the changes in level of these dynein transcripts in response to deciliation, together with their sequence relatedness, suggests that 11 or more of these genes encode dynein isoforms that participate in regeneration of external cilia on the embryo, whereas the single gene whose deduced sequence closely resembles that of cytoplasmic dynein in other organisms appears not to be involved in this regeneration. The four consensus motifs for phosphate binding found previously in the beta heavy chain of sea urchin dynein are present in all five additional isoforms for which extended sequences have been obtained, suggesting that these sites play a significant role in dynein function. Sequence analysis of a approximately 400 amino acid region encompassing the putative hydrolytic ATP-binding site shows that the dynein genes fall into at least six distinct classes. Most of these classes in sea urchin have a high degree of sequence identity with one of the dynein heavy chain genes identified in Drosophila, indicating that the radiation of the dynein gene family into the present classes occurred at an early stage in the evolution of eukaryotes. Evolutionary changes in cytoplasmic dynein have been more constrained than those in the axonemal dyneins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.