ArticleProceedings of the National Academy of Sciences of the United States of America1994
Similarity between a ubiquitous promoter element in an ancient eukaryote and mammalian initiator elements.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 75 citations in OpenAlex.
- Characterization of the regulatory 5'-flanking region of bovine mucin 2 (MUC2) gene.Molecular and cellular biochemistry · 2021Article
- An in vitro characterisation of the Trichomonas vaginalis TATA box-binding proteins (TBPs).Parasitology research · 2019Article
- Regulation of gene expression in the protozoan parasite Entamoeba invadens: identification of core promoter elements and promoters with stage-specific expression patterns.International journal for parasitology · 2014Article
- Transcription and Maturation of mRNA in Dinoflagellates.Microorganisms · 2013Review
- The mouse B cell-specific mb-1 gene encodes an immunoreceptor tyrosine-based activation motif (ITAM) protein that may be evolutionarily conserved in diverse species by purifying selection.Molecular biology reports · 2012Article
- Novel core promoter elements and a cognate transcription factor in the divergent unicellular eukaryote Trichomonas vaginalis.Molecular and cellular biology · 2011Article
- Regulation of gene expression in protozoa parasites.Journal of biomedicine & biotechnology · 2010Review
- Phytophthora infestans: the plant (and R gene) destroyer.Molecular plant pathology · 2008Review
- Design of a zinc finger protein binding a sequence upstream of the A20 gene.BMC biotechnology · 2008Article
- Proteins of the glycine decarboxylase complex in the hydrogenosome of Trichomonas vaginalis.Eukaryotic cell · 2006Article
- Identification and biochemical characterization of serine hydroxymethyl transferase in the hydrogenosome of Trichomonas vaginalis.Eukaryotic cell · 2006Article
- Core promoter structure in the oomycete Phytophthora infestans.Eukaryotic cell · 2004Article
- Initiator recognition in a primitive eukaryote: IBP39, an initiator-binding protein from Trichomonas vaginalis.Molecular and cellular biology · 2001Article
- The application of databases and PCR in the cloning of glycosidase genes from the protozoan Tritrichomonas foetus.Molecular biotechnology · 2000Article
- Analysis of a ubiquitous promoter element in a primitive eukaryote: early evolution of the initiator element.Molecular and cellular biology · 1999Article
- Transcription initiation is controlled by three core promoter elements in the hgl5 gene of the protozoan parasite Entamoeba histolytica.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Transient and selectable transformation of the parasitic protist Trichomonas vaginalis.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Presence of a mitochondrial-type 70-kDa heat shock protein in Trichomonas vaginalis suggests a very early mitochondrial endosymbiosis in eukaryotes.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- The sequence and organization of the core histone H3 and H4 genes in the early branching amitochondriate protist Trichomonas vaginalis.Journal of molecular evolution · 1996Article
- Transcription in the early diverging eukaryote Trichomonas vaginalis: an unusual RNA polymerase II and alpha-amanitin-resistant transcription of protein-coding genes.Journal of molecular evolution · 1996Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
To identify regulatory elements that play a role in transcription initiation in ancient eukaryotes, we have analyzed the upstream regions of protein-coding genes from Trichomonas vaginalis, one of the most ancient eukaryotes studied to date. Characterization of seven protein-coding genes from this protist invariably revealed the presence of a highly conserved DNA sequence motif immediately upstream of the coding region. This 13-nt motif was shown to surround and contain precise sites for transcription initiation. No typical TATA boxes, positioned at 25-30 nt upstream of the transcription start sites of these genes, were found. The start-site regions from all seven T. vaginalis genes impart strong specific initiation of transcription in a mammalian in vitro transcription assay. This consensus promoter element in an ancient eukaryote is similar, both structurally and functionally, to initiator elements found in promoters of higher eukaryotes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.