ArticleProceedings of the National Academy of Sciences of the United States of America1994
Voltage-dependent sodium channels develop in rat retinal pigment epithelium cells in culture.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 34 citations in OpenAlex.
- Sodium channels in non-excitable cells: powerful actions and therapeutic targets beyond Hodgkin and Huxley.Trends in cell biology · 2025Review
- The retinal pigment epithelium displays electrical excitability and lateral signal spreading.BMC biology · 2023Article
- Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium.BMC biology · 2019Article
- In Pursuit of Authenticity: Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Clinical Applications.Stem cells translational medicine · 2016Article
- ZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epithelium.Journal of molecular neuroscience : MN · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Whole-cell patch-clamp recordings were made from isolated cells of the retinal pigment epithelium (RPE) of neonatal rats. After 24 hr in cell culture, RPE cells developed a transient, voltage-activated inward current that was never observed in acutely isolated cells. The kinetics, voltage-dependence, and reversal potential of the current and its dependence on external sodium demonstrated that the current was due to the expression of voltage-activated Na+ channels in cultured RPE cells. The current was partly blocked by tetrodotoxin at low concentrations (< 100 nM), but a second component of Na+ current was unblocked by tetrodotoxin at concentrations up to 10 microM. Na+ channels were present in cultured RPE cells at sufficient density to support regenerative action potentials in voltage recordings. Both the epithelial cells of the RPE and the neurons of the retina derive embryonically from neural origin, and it is known that under certain circumstances, nonmammalian RPE cells retain the ability to take on neuronal characteristics. The development of voltage-activated Na+ channels and the presence of action potentials demonstrate that neonatal mammalian RPE cells are also capable of expressing neuronal characteristics in cell culture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.