ArticleProceedings of the National Academy of Sciences of the United States of America1994
SRY protein enhances transcription of Fos-related antigen 1 promoter constructs.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 75 citations in OpenAlex.
- Post-translational modification of proteins in the human testis development pathway.Human reproduction update · 2026Review
- Loss of Neurogenesis in Aging Hydra.Developmental neurobiology · 2019Article
- Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations.PloS one · 2011Article
- Review of the Y chromosome, Sry and hypertension.Steroids · 2010Review
- Calmodulin-dependent nuclear import of HMG-box family nuclear factors: importance of the role of SRY in sex reversal.The Biochemical journal · 2010Article
- SRY and the standoff in sex determination.Molecular endocrinology (Baltimore, Md.) · 2008Review
- Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- IRE-ABP (insulin response element-A binding protein), an SRY-like protein, inhibits C/EBPalpha (CCAAT/enhancer-binding protein alpha)-stimulated expression of the sex-specific cytochrome P450 2C12 gene.Molecular endocrinology (Baltimore, Md.) · 1998Article
- Searching for candidate genes with effects on an agonistic behavior, offense, in mice.Behavior genetics · 1996Review
- Molecular determinants of sexual differentiation.World journal of urology · 1996Review
- New genes for boys.American journal of human genetics · 1995Article
- Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron.Molecular and cellular biology · 1995Article
- Renal carcinogenesis in the Eker rat.Journal of cancer research and clinical oncology · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals, testis determination is under the control of the chromosome Y-linked SRY gene. Sry is expressed in the fetal mouse just before development of the testis and shows germ-cell-dependent expression in the adult mouse. SRY protein contains a high-mobility-group (HMG)-box DNA-binding domain, and potential target sequences have been identified. The fos-related antigen 1 (fra-1) gene is closely related to the protooncogene c-fos and encodes a component of transcription factor AP-1. Fra-1 is expressed during spermatogenesis, and the promoter of the rat fra-1 gene contains several potential binding sites for members of the HMG-box family of DNA-binding proteins. We demonstrate that purified SRY protein binds strongly to one of the putative fra-1 HMG-box response elements and that SRY enhances the transcription of rat fra-1 promoter constructs in cotransfection experiments. These results suggest that the function of HMG-box transcription factors may be mediated, in part, by activation of members of the AP-1 transcription factor family.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.